MV1 - 10mM in DMSO , CAS No.1001600-54-9

CAS: 1001600-54-9 Cat. No.: M655714 Formule: C₃₃H₄₄N₄O₅ Poids moléculaire: 576.73 PubChem CID: 23657865

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand.

In Vitro

MV1 (0.08-20 μM; 24 h) inhibits the growth of EVSAT cells. MV1 (5 μM; 0-60 min) treatment causes rapid loss of c-IAP1 and c-IAP2 in MDA-MB-231 cells. MV1 (5 μM; 1 h) treatment inducing degradation of c-IAP1 and c-IAP2 is dependent on proteasomal machinery but not on caspase activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: EVSAT cells Concentration: 0.08-20 μM Incubation Time: 24 hours Result: Showed IC 50 value of 5 μM for EVSAT cells. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 5 μM Incubation Time: 0-60 min Result: Showed the decreasement of c-IAP1 and 2 protein levels by as early as two minutes following exposure.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Isomères SMILES: C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)OC)NC
• PubChem CID: 23657865
• Poids moléculaire: 576.73