NAMI-A - ≥98% , CAS No.201653-76-1

CAS: 201653-76-1 Cat. No.: N646402 Formule: C₈H₁₅Cl₄N₄ORuS Poids moléculaire: 458.18

GRADE & PURITY ≥98%

Synonyms

60487Z56XW | 1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-kappaN3)(1,1'-(sulfinyl-kappaS)bis(methane))ruthenate(1-) (1:1) | NAMI-A | 1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride | BIA65376 | 1H-IMIDAZOLE (OC-6-11)-TE

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration.In vitro: NAMI-A can significantly affect tumor cells with metastatic ability.The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations.The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.In vivo: The reference for NAMI-A is 35 mg/kg/day.

Form:Solid

Specifications

Synonymes

60487Z56XW | 1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-kappaN3)(1,1'-(sulfinyl-kappaS)bis(methane))ruthenate(1-) (1:1) | NAMI-A | 1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride | BIA65376 | 1H-IMIDAZOLE (OC-6-11)-TE

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration.\nIn vitro: NAMI-A can significantly affect tumor cells with metastatic ability.\nThe half lifetime of NAMI-A elimina

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥98%

Noms et identifiants

• Sourires canoniques: CS(=O)C.C1=C[NH+]=CN1.C1=CN=CN1.[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3]
• IUPAC Name: 1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride
• InChIKey: RJZBTXZRLXLLKO-UHFFFAOYSA-K
• INCHI: 1S/2C3H4N2.C2H6OS.4ClH.Ru/c2*1-2-5-3-4-1;1-4(2)3;;;;;/h2*1-3H,(H,4,5);1-2H3;4*1H;/q;;;;;;;+3/p-3
• Isomères SMILES: CS(=O)C.C1=C[NH+]=CN1.C1=CN=CN1.[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3]
• Poids moléculaire: 458.18
• Reaxy-Rn: 20389650
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20389650&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Imidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Imidazoles
• Alternative Parents: Heteroaromatic compounds Sulfoxides Sulfinyl compounds Organic transition metal salts Organic metal halides Azacyclic compounds Organonitrogen compounds Organic oxides Organic chloride salts Hydrocarbon derivatives Organic cations
• Molecular Framework: Not available
• Substituents: Imidazole - Heteroaromatic compound - Sulfoxide - Sulfinyl compound - Organic transition metal salt - Organic metal salt - Azacycle - Organic metal halide - Organic nitrogen compound - Organic chloride salt - Organic salt - Organonitrogen compound - Organosulfur compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organic cation - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as imidazoles. These are compounds containing an imidazole ring, which is an aromatic five-member ring with two nitrogen atoms at positions 1 and 3, and three carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriétés chimiques et physiques

• Solubilité: H2O : 8.28 mg/mL (18.07 mM; Need ultrasonic and warming)

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 201653-76-1, the molecular formula is C8H15Cl4N4ORuS, and the molecular weight is 458.18 g/mol. InChIKey RJZBTXZRLXLLKO-UHFFFAOYSA-K.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.