for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Vue d’ensemble
Nanaomycin A is the first selective DNMT3B inhibitor with an IC 50 of 500 nM. Nanaomycin A, a quinone antibiotics , reactivates silenced tumor suppressor genes in human cancer cells Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC 80 value of 33.1 nM .
In Vitro
Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines. Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells. Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction. Nanaomycin A not affects the enzymatic activity of DNMT1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines Concentration: 10, 100, 1000, 10000 nM Incubation Time: 72 hours Result: Had a distinct cytotoxic effect in all three cell lines. Western Blot AnalysisCell Line: A549 cells Concentration: 0.5, 5 μM Incubation Time: 72 hours Result: Revealed induction of RASSF1A protein expression. RT-PCRCell Line: A549 cells Concentration: 5 μM Incubation Time: 72 hours Result: Had an 18-fold relative induction.
Form:Solid
IC50& Target:DNMT3B 500 nM (IC 50 ) Plasmodium
Specifications
Mécanismes biochimiques et physiologiques
Nanaomycin A is the first selective DNMT3B inhibitor with an IC 50 of 500 nM. Nanaomycin A, a quinone antibiotics , reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite
Conditions de stockage de stockage
Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propriétés chimiques et physiques
Solubilité
DMSO : 100 mg/mL (330.82 mM; Need ultrasonic)
Poids moléculaire
302.280 g/mol
XLogP3
1.300
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
2
Exact Mass
302.079 Da
Monoisotopic Mass
302.079 Da
Topological Polar Surface Area
101.000 Ų
Heavy Atom Count
22
Formal Charge
0
Complexity
563.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
2
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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Avis
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Foire aux questions
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 52934-83-5, the molecular formula is C16H14O6, and the molecular weight is 302.28 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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