NCGC00247743 - 10mM in DMSO , CAS No.1435192-04-3

CAS: 1435192-04-3 Cat. No.: N656642 Formule: C₂₄H₂₉N₃O₂ Poids moléculaire: 391.51 PubChem CID: 89564218

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

In Vitro

Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC 50 s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:KDM4

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

Isomères SMILES

CN(C)CCCCCCNC(=O)C1=CC=CC(=C1)C2=CC(=C3C(=C2)C=CC=N3)O

PubChem CID

89564218

Poids moléculaire

391.51