NDMC101 - ≥98% , CAS No.1308631-40-4

CAS: 1308631-40-4 Cat. No.: N412581 Formule: C₁₃H₉ClFNO₂ Poids moléculaire: 265.67 Numéro CE: 808-917-5

QUALITÉ & PURETÉ ≥98%

Synonyms

HS-Cm | A900355 | NCGC00402296-03 | AS-16724 | AKOS009125225 | 1308631-40-4 | SCHEMBL12099327 | ndmc101 | NDMC101, >=98% (HPLC) | NUQWCDAXACRITO-UHFFFAOYSA-N | HY-124958 | NSC812943 | NSC-812943 | N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide | N-(4-chlo

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

NDMC101 is a potent inhibitor of osteoclastogenesis that inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene express. NDMC101 is also a significant inhibitor of early T-cell activation via DPP4 inhibition.NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al。

Spécifications

Synonymes

HS-Cm | A900355 | NCGC00402296-03 | AS-16724 | AKOS009125225 | 1308631-40-4 | SCHEMBL12099327 | ndmc101 | NDMC101, >=98% (HPLC) | NUQWCDAXACRITO-UHFFFAOYSA-N | HY-124958 | NSC812943 | NSC-812943 | N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide | N-(4-chlo

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

NDMC101 is a potent inhibitor of osteoclastogenesis that inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene express. NDMC101 is also a significant inhibitor of early T-cell activation via DPP4 inhibition.NDMC101 (HS Cm) is a

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥98%

Noms et identifiants

Pubchem Sid

504771808

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504771808

Sourires canoniques

C1=CC=C(C(=C1)C(=O)NC2=C(C=C(C=C2)Cl)F)O

IUPAC Name

N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide

InChIKey

NUQWCDAXACRITO-UHFFFAOYSA-N

INCHI

1S/C13H9ClFNO2/c14-8-5-6-11(10(15)7-8)16-13(18)9-3-1-2-4-12(9)17/h1-7,17H,(H,16,18)

Isomères SMILES

C1=CC=C(C(=C1)C(=O)NC2=C(C=C(C=C2)Cl)F)O

Poids moléculaire

265.67

Reaxy-Rn

22843942

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22843942&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Benzanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides
• Direct Parent: Benzanilides
• Alternative Parents: Salicylamides Benzamides Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Fluorobenzenes Chlorobenzenes Aryl chlorides Aryl fluorides Vinylogous acids Secondary carboxylic acid amides Hydrocarbon derivatives Organic oxides Organochlorides Organofluorides Organonitrogen compounds Organooxygen compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzanilide - Salicylic acid or derivatives - Salicylamide - Benzamide - Benzoic acid or derivatives - Benzoyl - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Chlorobenzene - Fluorobenzene - Halobenzene - Aryl chloride - Aryl fluoride - Aryl halide - Vinylogous acid - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Organofluoride - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organochloride - Organohalogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: light sensitive
• Poids moléculaire: 265.670 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 265.031 Da
• Monoisotopic Mass: 265.031 Da
• Topological Polar Surface Area: 49.300 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 303.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1