NDSB-195 - ≥97% , CAS No.160255-06-1

CAS: 160255-06-1 Cat. No.: N275347 Molecular Weight: 195.28 EC Number: 627-262-4

GRADE & PURITY ≥97%

Synonyms

Dimethylethylammoniumpropane sulfonate | ETHYL DIMETHYL AMMONIO PROPANE SULFONATE | HY-135484 | SY347253 | 3-(Ethyldimethylammonio)propane-1-sulfonate | NDSB-195 | DIMETHYLETHYL-(3-SULFOPROPYL)AMMONIUM, INNER SALT | Dimethylethyl-(3-sulfopropyl)ammonium,i

Storage

Room temperature,Argon charged

Shipped In

Normal

Overview

Dimethylethylammoniumpropane sulfonate is a zwitterionic solubilizing agent with usefulness in protein crystallization.

Product Application

Dimethylethylammoniumpropane sulfonate has been used in a study to assess the functional properties of the separate subunits of the human DNA helicase II/Ku autoantigen. It has also been used in a study to investigate the swelling behaviors of copolymeric hydrogels in various saline solutions.

Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification.

Specifications

Synonyms

Dimethylethylammoniumpropane sulfonate | ETHYL DIMETHYL AMMONIO PROPANE SULFONATE | HY-135484 | SY347253 | 3-(Ethyldimethylammonio)propane-1-sulfonate | NDSB-195 | DIMETHYLETHYL-(3-SULFOPROPYL)AMMONIUM, INNER SALT | Dimethylethyl-(3-sulfopropyl)ammonium, i

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Zwitterionic non-detergent sulfobetaine. Used to extract, solubilise and crystallise proteins. Prevents protein aggregation and promotes renaturation of denatured proteins.

Storage

Room temperature, Argon charged

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488195164
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195164
• Canonical Smiles: CC[N+](C)(C)CCCS(=O)(=O)[O-]
• IUPAC Name: 3-[ethyl(dimethyl)azaniumyl]propane-1-sulfonate
• InChIKey: NNCRHRDBFDCWPA-UHFFFAOYSA-N
• INCHI: 1S/C7H17NO3S/c1-4-8(2,3)6-5-7-12(9,10)11/h4-7H2,1-3H3
• Isomeric SMILES: CC[N+](C)(C)CCCS(=O)(=O)[O-]
• Molecular Weight: 195.28
• Reaxy-Rn: 7201699
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7201699&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic sulfonic acids and derivatives
      • Subclass Organosulfonic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic sulfonic acids and derivatives
• Subclass: Organosulfonic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Organosulfonic acids
• Alternative Parents: Tetraalkylammonium salts Sulfonyls Alkanesulfonic acids Organopnictogen compounds Organic salts Organic oxides Hydrocarbon derivatives Amines
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Tetraalkylammonium salt - Alkanesulfonic acid - Sulfonyl - Organosulfonic acid - Quaternary ammonium salt - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organosulfur compound - Organonitrogen compound - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as organosulfonic acids. These are compounds containing the sulfonic acid group, which has the general structure RS(=O)2OH (R is not a hydrogen atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water to 100 mM
• Sensitivity: Moisture sensitive.
• Molecular Weight: 195.280 g/mol
• XLogP3: -0.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.093 Da
• Monoisotopic Mass: 195.093 Da
• Topological Polar Surface Area: 65.600 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 202.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1