Nelonicline - ≥99% , CAS No.1026134-63-3

CAS: 1026134-63-3 Cat. No.: N646910 Molecular Weight: 313.42 PubChem CID: 24987875

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

Overview

Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain ( K i =12.3 nM). Nelonicline is used for the research of shizophrenia and Alzheimer's disease

In Vitro

Nelonicline is an agonist that binds with high affinity to α7 nAChRs in human brain (K i = 12.3 nM) and activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC 50 =2 μM; intrinsic activity of 74% relative to acetylcholine). Nelonicline does bind to α3β4* nAChRs in human IMR-32 neuroblastoma cells (K i =60 nM), but has only 12% efficacy at 100,000 nM in a calcium flux assay in these cell. Like some other α7 nAChR agonists, Nelonicline is also a 5-HT3 receptor antagonist, but it has >10-fold lower affinity for this receptor than for α7 nAChRs (K i of 140 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Neuronal nicotinic receptor

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain ( K i =12.3 nM). Nelonicline is used for the research of shizophrenia and Alzheimer's disease.

Storage

Store at 2-8°C, Argon charged, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥99%

Names and Identifiers

• Isomeric SMILES: C1C2CC3CN(C2)CC1C3OC4=NN=C(S4)C5=CC=CC=C5
• PubChem CID: 24987875
• Molecular Weight: 313.42

Chemical and Physical Properties

• Solubility: DMSO : 12.5 mg/mL (39.88 mM; ultrasonic and warming and heat to 60°C)
• Molecular Weight: 313.400 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 313.125 Da
• Monoisotopic Mass: 313.125 Da
• Topological Polar Surface Area: 66.500 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 401.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1