Neoseptin 3 - 10mM in DMSO , CAS No.1622863-21-1

CAS: 1622863-21-1 Cat. No.: N655803 Molecular Weight: 474.59 EC Number: 110-749-6 PubChem CID: 77461013

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 ( mTLR4/MD-2 ) agonist with an EC 50 of 18.5 μM.

In Vitro

Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC 50 of 18.5 μM. Neoseptin-3 induces TNFα production by macrophages in a concentration-dependent manner. Neoseptin-3 induces phosphorylation of IκB kinases α (IKKα), IKKβ, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IκBα, consistent with activation of MAPK and canonical NF-κB signaling. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also increase in response to Neoseptin-3. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:TLR4 18.5 μM (EC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 ( mTLR4/MD-2 ) agonist with an EC 50 of 18.5 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Names and Identifiers

• Isomeric SMILES: CC(C)(C)OC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)C2=CC(=C(C=C2)N)CCC3=CC=C(C=C3)O
• PubChem CID: 77461013
• Molecular Weight: 474.59