NQTrp - ≥95% , CAS No.185351-19-3

CAS: 185351-19-3 Cat. No.: N286859 Formule: C₂₁H₁₆N₂O₄ Poids moléculaire: 360.36 Numéro CE: 808-550-0

GRADE & PURITY ≥95%

Synonyms

NQTrp, >=98% (HPLC) | DTXSID30717912 | (1,4-dioxo-1,4-dihydronaphthalen-2-yl)-L-tryptophan | 1,4-naphthoquinon-2-yl-l-tryptophan | AKOS027470177 | nqtrp | HY-19738 | (2S)-2-[(1,4-DIOXONAPHTHALEN-2-YL)AMINO]-3-(1H-INDOL-3-YL)PROPANOIC ACID | MS-25694 | N-(

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonymes

NQTrp, >=98% (HPLC) | DTXSID30717912 | (1,4-dioxo-1,4-dihydronaphthalen-2-yl)-L-tryptophan | 1,4-naphthoquinon-2-yl-l-tryptophan | AKOS027470177 | nqtrp | HY-19738 | (2S)-2-[(1,4-DIOXONAPHTHALEN-2-YL)AMINO]-3-(1H-INDOL-3-YL)PROPANOIC ACID | MS-25694 | N-(

Spécifications et pureté

≥95%

Mécanismes biochimiques et physiologiques

Potent inhibitor of Aβoligomer and fibril formation (IC50= 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβoligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-4

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥95%

Noms et identifiants

• Pubchem Sid: 504771422
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504771422
• Sourires canoniques: C1=CC=C2C(=C1)C(=O)C=C(C2=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O
• IUPAC Name: (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
• InChIKey: DZZUYZXINNHEGM-SFHVURJKSA-N
• INCHI: 1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1
• Isomères SMILES: C1=CC=C2C(=C1)C(=O)C=C(C2=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O
• Poids moléculaire: 360.36
• Reaxy-Rn: 25282926
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25282926&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Indolyl carboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Indolyl carboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Indolyl carboxylic acids and derivatives
• Alternative Parents: Naphthoquinones 3-alkylindoles L-alpha-amino acids Quinones Aryl ketones Aralkylamines Substituted pyrroles Vinylogous amides Heteroaromatic compounds Monocarboxylic acids and derivatives Enamines Dialkylamines Carboxylic acids Azacyclic compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolyl carboxylic acid derivative - Naphthoquinone - Alpha-amino acid - Alpha-amino acid or derivatives - L-alpha-amino acid - Naphthalene - 3-alkylindole - Indole - Quinone - Aryl ketone - Aralkylamine - Substituted pyrrole - Benzenoid - Vinylogous amide - Pyrrole - Heteroaromatic compound - Ketone - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Enamine - Azacycle - Monocarboxylic acid or derivatives - Amine - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Carbonyl group - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. These are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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BCHE Tclin Butyrylcholinesterase (7174 Activities)

Discover Target: BCHE

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APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 36.04, Max Conc. mM: 100
• Poids moléculaire: 360.400 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 360.111 Da
• Monoisotopic Mass: 360.111 Da
• Topological Polar Surface Area: 99.300 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 659.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 185351-19-3, the molecular formula is C21H16N2O4, and the molecular weight is 360.36 g/mol. InChIKey DZZUYZXINNHEGM-SFHVURJKSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.