NRD167 , CAS No.2166487-23-4

CAS: 2166487-23-4 Cat. No.: N419999

Synonyms

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Sequence:Z-Lys(thiourea-beta-Ala-OEt)-Trp-Isopropylamine

Specifications

Synonymes

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Mécanismes biochimiques et physiologiques

RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SI

Conditions de stockage de stockage

Protected from light,Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Propriétés chimiques et physiques

• Solubilité: DMSO: 2 mg/mL, clear
• Sensibilité: Light sensitive

Références

1. Zekun Liu, Jie Hu, Yinan Lin, Chuang Ge, Yuru Shao, Mengmeng Bao, Mengjie Liu, Shilin Jia, Yating Li, Xiaozhi Xu, Ruiyan Li, Qizhou Jiang, Fangrong Yan, Fei Xiao, Junmei Ye.  (2025)  SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.  LIVER INTERNATIONAL,  45  (12): (e70433).  [PMID:41221659] [10.1111/liv.70433]