NRX-252114 - ≥99% , CAS No.2763260-39-3

CAS: 2763260-39-3 Cat. No.: N651917 Formule: C₂₂H₁₂Cl₂F₃N₃O₂S Poids moléculaire: 510.32

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

NRX-252114 is a potent enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC 50 of 6.5 nM and a K d of 0.4 nM. NRX-252114 induces mutant β-catenin degradation

In Vitro

NRX-252114 (20 μM) enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP, with more than 1500-fold co-operativity. NRX-252114 (0-25 μM) increases the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains. NRX-252114 (0-25 μM) enhances the ubiquitylation of S33E/S37A β-catenin protein, as well as unphosphorylated Ser33/S37A β-catenin peptides. NRX-252114 (20 μM, 6 h) results in robust S33E/S37A β-catenin:β-TrCP interaction in the transfected HEK293T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 6.5 nM (β-catenin:β-TrCP Interaction), Kd: 0.4 nM (β-catenin:β-TrCP Interaction)

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

NRX-252114 is a potent enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC 50 of 6.5 nM and a K d of 0.4 nM. NRX-252114 induces mut

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

• Poids moléculaire: 510.32

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (195.96 mM; Need ultrasonic)

Foire aux questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2763260-39-3, the molecular formula is C22H12Cl2F3N3O2S, and the molecular weight is 510.32 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.