NRX-2663 - ≥98% , CAS No.2763260-34-8

CAS: 2763260-34-8 Cat. No.: N649316 Formule: C₂₀H₁₃F₃N₂O₅ Poids moléculaire: 418.32

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

NRX-2663 is an enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC 50 of 22.9 µM and a K d of 54.8 nM

In Vitro

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC 50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 22.9 µM (β-catenin:β-TrCP Interaction), Kd: 54.8 nM (β-catenin:β-TrCP Interaction)

Specifications

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

NRX-2663 is an enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC 50 of 22.9 µM and a K d of 54.8 nM.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥98%

Noms et identifiants

• Poids moléculaire: 418.32