Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC 50 of 77 nM for human PPARα , shows high selectivity over other nuclear hormone receptor, such as PPARδ , PPARγ , ERβ , GR and TRβ, IC 50 s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models .
In Vitro
NXT629 (Compound 33) is a potent, selective PPAR-α antagonist, with an IC 50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, Erβ, GR and TRβ, IC 50 s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 also competitively inhibits mousse PPARα, PPARβ/δ and PPARγ, with IC 50 s of 2.3, 35.1, 6.9 μM, resepctively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
NXT629 (Compound 33; 30 mg/kg, i.p.) exhibits good pharmacokinetics in mouse, and significantly decreases Fgf21 (Fibroblast growth factor 21), a PPARα target gene in fasted mice . NXT629 has poor oral bioavailability in mice and rats. NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice. NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis. NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:hPPARα|77 nM (IC|50|)|hPPARδ|6 μM (IC|50|)|hPPARγ|15 μM (IC|50|)|ERβ|15.2 μM (IC|50|)|GR|32.5 μM (IC|50|)
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Pyridines and derivatives |
| Subclass | Phenylpyridines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylpyridines |
| Alternative Parents | Benzenesulfonamides Phenylpropanes Benzenesulfonyl compounds Organosulfonamides Triazoles Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | 2-phenylpyridine - Benzenesulfonamide - Benzenesulfonyl group - Phenylpropane - Monocyclic benzene moiety - Benzenoid - Organosulfonic acid amide - Azole - Heteroaromatic compound - Aminosulfonyl compound - 1,2,4-triazole - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Solubilité | DMSO : 125 mg/mL (204.99 mM; Need ultrasonic) |
|---|---|
| Poids moléculaire | 609.800 g/mol |
| XLogP3 | 6.500 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 12 |
| Exact Mass | 609.277 Da |
| Monoisotopic Mass | 609.277 Da |
| Topological Polar Surface Area | 103.000 Ų |
| Heavy Atom Count | 44 |
| Formal Charge | 0 |
| Complexity | 1060.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
No vendor-verified application protocols are provided for NXT629 in the Product Data. The following is generic guidance for handling small molecules in research settings; adjust to your assay and institutional SOPs.
Preparing stock solutions (general):
Making working solutions:
Plate-based assays (general tips):
Stability checks:
For item-specific protocols (e.g., recommended assay concentrations or controls), refer to your internal validation or contact us with your application details.
No biological mechanism, target class, or pathway information is provided for NXT629 in the Product Data. Therefore, no item-specific biological roles can be stated.
General considerations for small-molecule library members:
Data needed to define roles (not provided here):
As currently listed, NXT629 is supplied strictly for research use, with no implied biological role. Consult the CoA/Spec Sheet and your internal validation data to assign any functional annotations.
This product is a small-molecule library compound, not a buffering reagent. Consequently, standard buffer system recipes and pH ranges are not directly applicable.
For application-specific buffer guidance, rely on your assay SOPs and validate compatibility with this compound experimentally.
NXT629 is a research compound, not a process solvent or reagent. Green chemistry considerations therefore focus on the choice of handling solvents, workup practices, and analytics rather than on replacing the compound itself.
Preferable solvent choices (general guidance):
Workup and waste minimization:
Comparison snapshot (general; not item-specific):
Balance green choices with data quality and target biology; validate that greener solvent swaps do not alter assay outcomes (e.g., nonspecific binding or readout interference).
No pharmacopeial status, excipient role, or formulation use is provided for NXT629. This product is supplied strictly for research use only and is not intended for human or veterinary use.
General R&D formulation context (not item-specific):
What would be needed for formulation work (not provided here):
No pharmaceutical or clinical claims are made or implied for this item.
Item-specific physical constants are not provided in the current Product Data.
Item-specific data:
Practical guidance (general, for small-molecule library members; not item-specific):
Always refer to the product’s CoA/Spec Sheet for authoritative physical data specific to this lot.
Item-specific grade and purity are not listed in the Product Data.
Item-specific status:
Guidance on common grades (general context):
What to verify on the CoA for this item:
If your application requires enhanced purity (e.g., sub-ppm metal content or low UV background), contact us for the most recent lot-specific CoA or discuss custom purification.
The Product Data list NXT629 within a small-molecule/compound library; no specific synthetic or application notes are provided. Accordingly, the following are general research applications and best practices rather than item-specific claims.
Typical research uses (general):
Practical considerations:
Data package recommended before deployment:
Please consult the CoA or contact us for any item-specific application guidance once full structure/solubility details are confirmed.
No reaction chemistry is defined for this catalog entry because NXT629 is offered as a finished small molecule rather than a reagent. In the absence of a known structure, specific conditions (solvents, catalysts, temperatures) cannot be recommended for transformations of this compound.
If derivatization is planned (general advice only):
Analytical conditions (general, for method development):
For any reaction planning, secure the definitive structure and consult primary literature for closely related scaffolds.
Safety information specific to this item is not provided in the Product Data and should be obtained from the SDS.
Item-specific safety fields:
General laboratory precautions (for small organic research compounds; not item-specific):
First-aid overview (general):
Spill/accidental release (general):
Always defer to the official SDS for hazard classification and detailed response procedures.
No item-specific solubility data are provided. The following is general guidance for dissolving and handling small-molecule library members like NXT629; verify with your own solubility tests.
Primary stock solvents (general):
Aqueous compatibility (general):
Practical tips:
Comparison snapshot (general):
Always confirm final solvent composition does not interfere with your assay readout.
Item-specific storage and shipping information are provided; reconstitution specifics are not.
Item-specific details (from Product Data):
General handling and reconstitution guidance (not item-specific):
Stability notes:
For any discrepancies between this guidance and your institutional SOPs or the SDS/CoA, follow the SDS/CoA and institutional requirements.
Brief overview: NXT629 (SKU N651282) is listed in our small-molecule/compound library collection. Structural identifiers are only partially provided for this catalog entry.
Item-specific identifiers (from Product Data):
Structure description:
Guidance for identity confirmation (general best practice):
NXT629 is listed as a discrete small-molecule library member, not as a synthetic building block or reagent. Without a disclosed structure, no item-specific reactivity or functional-group guidance can be provided.
General notes (applicability depends on actual structure):
Recommendations before any derivatization:
Given the current information, treat NXT629 as an end-use screening compound rather than a synthetic intermediate.
Item-specific biological target information is not provided in the Product Data for NXT629.
If you possess internal data identifying the molecular target(s), we recommend documenting:
Please contact us if you wish to append verified target specificity data to this catalog entry.