NXT629 - ≥99% , CAS No.1454925-59-7

CAS: 1454925-59-7 Cat. No.: N651282 Formule: C35H39N5O3S Poids moléculaire: 609.78 PubChem CID: 71721539
DISPONIBLE À COMMANDE
QUALITÉ & PURETÉ ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Taille
Allemagne (EU)
USA*
Prix
Qté
5mg
N651282-5mg
Sur commande · 8–12 semaines
1 128,84€
10mg
N651282-10mg
Sur commande · 8–12 semaines
1 649,49€
25mg
N651282-25mg
Sur commande · 8–12 semaines
3 384,96€
50mg
N651282-50mg
Sur commande · 8–12 semaines
5 120,44€
100mg
N651282-100mg
Sur commande · 8–12 semaines
7 810,43€
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Vue d’ensemble

NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC 50 of 77 nM for human PPARα , shows high selectivity over other nuclear hormone receptor, such as PPARδ , PPARγ , ERβ , GR and TRβ, IC 50 s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models .

In Vitro

NXT629 (Compound 33) is a potent, selective PPAR-α antagonist, with an IC 50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, Erβ, GR and TRβ, IC 50 s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 also competitively inhibits mousse PPARα, PPARβ/δ and PPARγ, with IC 50 s of 2.3, 35.1, 6.9 μM, resepctively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NXT629 (Compound 33; 30 mg/kg, i.p.) exhibits good pharmacokinetics in mouse, and significantly decreases Fgf21 (Fibroblast growth factor 21), a PPARα target gene in fasted mice . NXT629 has poor oral bioavailability in mice and rats. NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice. NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis. NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:hPPARα|77 nM (IC|50|)|hPPARδ|6 μM (IC|50|)|hPPARγ|15 μM (IC|50|)|ERβ|15.2 μM (IC|50|)|GR|32.5 μM (IC|50|)

Spécifications

Spécifications et pureté
≥99%
Mécanismes biochimiques et physiologiques
NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC 50 of 77 nM for human PPARα , shows high selectivity over other nuclear hormone receptor, such as PPARδ , PPARγ , ERβ , GR and TRβ, IC 50 s are 6.0, 15, 15.2, 32.5 and >100 μM, r
Conditions de stockage de stockage
Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Type d'action
ANTAGONIST
Pureté
≥99%
Noms et identifiants
Sourires canoniques
CCN1C(=NN(C1=O)CC2=CC=C(C=C2)C(C)(C)C)CCCC3=CC=C(C=C3)C4=NC=C(C=C4)NS(=O)(=O)C5=CC=CC=C5
IUPAC Name
N-[6-[4-[3-[1-[(4-tert-butylphenyl)methyl]-4-ethyl-5-oxo-1,2,4-triazol-3-yl]propyl]phenyl]pyridin-3-yl]benzenesulfonamide
InChIKey
IRSFLNXJVJKMDT-UHFFFAOYSA-N
INCHI
1S/C35H39N5O3S/c1-5-39-33(37-40(34(39)41)25-27-16-20-29(21-17-27)35(2,3)4)13-9-10-26-14-18-28(19-15-26)32-23-22-30(24-36-32)38-44(42,43)31-11-7-6-8-12-31/h6-8,11-12,14-24,38H,5,9-10,13,25H2,1-4H3
Isomères SMILES
CCN1C(=NN(C1=O)CC2=CC=C(C=C2)C(C)(C)C)CCCC3=CC=C(C=C3)C4=NC=C(C=C4)NS(=O)(=O)C5=CC=CC=C5
PubChem CID
71721539
Termes d'entrée MeSH
NXT629
Poids moléculaire
609.78

Données avancées

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassePyridines and derivatives
SubclassPhenylpyridines
Intermediate Tree Nodes Not available
Direct ParentPhenylpyridines
Alternative Parents Benzenesulfonamides  Phenylpropanes  Benzenesulfonyl compounds  Organosulfonamides  Triazoles  Heteroaromatic compounds  Aminosulfonyl compounds  Azacyclic compounds  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents 2-phenylpyridine - Benzenesulfonamide - Benzenesulfonyl group - Phenylpropane - Monocyclic benzene moiety - Benzenoid - Organosulfonic acid amide - Azole - Heteroaromatic compound - Aminosulfonyl compound - 1,2,4-triazole - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
External Descriptors Not available
Structure 3D
Modèle de structure chimique interactif





Cibles associées (humaines)
PPARA Tclin Peroxisome proliferator-activated receptor alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cibles associées (non humaines)
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mécanismes d'action
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propriétés chimiques et physiques
SolubilitéDMSO : 125 mg/mL (204.99 mM; Need ultrasonic)
Poids moléculaire609.800 g/mol
XLogP36.500
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count12
Exact Mass609.277 Da
Monoisotopic Mass609.277 Da
Topological Polar Surface Area103.000 Ų
Heavy Atom Count44
Formal Charge0
Complexity1060.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculateurs de solution
Avis

Avis des clients

Application Protocols

No vendor-verified application protocols are provided for NXT629 in the Product Data. The following is generic guidance for handling small molecules in research settings; adjust to your assay and institutional SOPs.

  • Preparing stock solutions (general):

    • Equilibrate vial to room temperature before opening to reduce condensation.
    • Dissolve compound in anhydrous DMSO to 10–50 mM. Vortex/sonicate gently. Filter through 0.2 µm PTFE if needed and compatible.
    • Aliquot into small, headspace-minimized, amber vials or 96-well plates; store at −20°C.
  • Making working solutions:

    • Dilute DMSO stock into assay buffer or media to the desired concentration, maintaining acceptable final DMSO (typically ≤0.1–1% v/v).
    • Inspect for precipitation; if observed, lower concentration, add minimal co-solvent, or pre-warm.
  • Plate-based assays (general tips):

    • Pre-dispense solvent controls matching the highest final DMSO content.
    • Include counterscreens for fluorescence/absorbance interference and aggregation.
  • Stability checks:

    • Reassess by LC–MS after multiple freeze–thaw cycles; consider single-use aliquots to avoid degradation.

For item-specific protocols (e.g., recommended assay concentrations or controls), refer to your internal validation or contact us with your application details.

Biological Roles

No biological mechanism, target class, or pathway information is provided for NXT629 in the Product Data. Therefore, no item-specific biological roles can be stated.

  • General considerations for small-molecule library members:

    • Such compounds may be evaluated as chemical probes in cell-free biochemical assays, cell-based phenotypic assays, or target-engagement platforms (e.g., CETSA, NanoBRET), but this is application-dependent and not specific to NXT629.
    • Prior to biological testing, confirm identity, purity, absence of reactive impurities, and solubility in assay-relevant media at intended concentrations.
    • Evaluate potential assay interferences (fluorescence, redox cycling, aggregation) and include appropriate counterscreens.
  • Data needed to define roles (not provided here):

    • Confirmed molecular target(s) and potency metrics (e.g., IC50/Ki) in defined assay conditions.
    • Selectivity panels (on-/off-target), ADME properties (metabolic stability, permeability), and cytotoxicity profiling.

As currently listed, NXT629 is supplied strictly for research use, with no implied biological role. Consult the CoA/Spec Sheet and your internal validation data to assign any functional annotations.

Buffer Applications

This product is a small-molecule library compound, not a buffering reagent. Consequently, standard buffer system recipes and pH ranges are not directly applicable.

  • Practical notes (general):
    • When preparing assay solutions, dissolve in DMSO to make a concentrated stock, then dilute into the desired buffer (e.g., PBS, HEPES, Tris) ensuring the final organic co-solvent level is acceptable for your assay (commonly ≤0.1–1% v/v).
    • If precipitation occurs on dilution, adjust by adding a small percentage of co-solvent, warming gently, or reducing final concentration.
    • Filter sterilization (0.2 µm) may be appropriate for cell-based assays if the compound and vehicle tolerate filtration; verify no adsorption losses on the membrane.

For application-specific buffer guidance, rely on your assay SOPs and validate compatibility with this compound experimentally.

Green Alternatives

NXT629 is a research compound, not a process solvent or reagent. Green chemistry considerations therefore focus on the choice of handling solvents, workup practices, and analytics rather than on replacing the compound itself.

  • Preferable solvent choices (general guidance):

    • Replace DMF/NMP where possible with acetonitrile, ethanol, isopropanol, or water-rich mixtures compatible with your assay.
    • For synthetic steps involving the compound (if any), consider 2-MeTHF or CPME in place of traditional ethers; and EtOAc over chlorinated solvents when feasible.
  • Workup and waste minimization:

    • Use microscale or microplate formats to reduce solvent volume in screening.
    • Consolidate DMSO-containing aqueous waste separately for appropriate disposal.
    • Opt for UPLC over HPLC to cut solvent usage in routine analytical runs.
  • Comparison snapshot (general; not item-specific):

    • 2-MeTHF vs THF: improved sustainability, higher boiling point, often comparable solubility for organics.
    • EtOAc vs DCM: lower toxicity and better environmental profile; check assay compatibility.
    • MeCN vs MeOH: MeCN offers lower viscosity and good MS compatibility but consider sourcing and waste.

Balance green choices with data quality and target biology; validate that greener solvent swaps do not alter assay outcomes (e.g., nonspecific binding or readout interference).

Pharmaceutical Uses

No pharmacopeial status, excipient role, or formulation use is provided for NXT629. This product is supplied strictly for research use only and is not intended for human or veterinary use.

  • General R&D formulation context (not item-specific):

    • For in vitro studies, compounds are often handled as DMSO stocks and diluted into assay media.
    • For preclinical exploratory work (non-clinical), vehicles may include PEG400/saline, Captisol, or lipid-based systems; such use requires independent verification of solubility, stability, and tolerability and is outside the scope of this listing.
  • What would be needed for formulation work (not provided here):

    • Solid-state form (free base/acid vs salt), polymorph, and water content.
    • Degradation pathways (hydrolysis, oxidation, photolysis) and pH/stress stability.
    • Residual solvent profile and impurity limits.

No pharmaceutical or clinical claims are made or implied for this item.

Physical Properties

Item-specific physical constants are not provided in the current Product Data.

  • Item-specific data:

    • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
    • Melting point (MP): Not specified for this item; refer to CoA/Spec Sheet.
    • Boiling point (BP): Not specified for this item; refer to CoA/Spec Sheet.
    • Density: Not specified for this item; refer to CoA/Spec Sheet.
    • Solubility profile: Not specified for this item; refer to CoA/Spec Sheet.
    • LogP / pKa / refractive index: Not specified for this item; refer to CoA/Spec Sheet.
  • Practical guidance (general, for small-molecule library members; not item-specific):

    • Many discovery compounds are formulated or stored as DMSO stocks. If neat solid/liquid is supplied, begin solubility testing with dry DMSO, then evaluate DMF, acetonitrile, methanol, and buffered aqueous mixtures (e.g., PBS + ≤2% DMSO or 10–20% co-solvent) as needed.
    • For analytical characterization, develop an LC–MS method using mixed aqueous (0.1% formic acid or 10 mM ammonium acetate) / acetonitrile gradients; screen both ESI+ and ESI−.
    • Hygroscopicity, polymorph, or salt-form behavior can affect apparent MP and solubility. Confirm form on the CoA and, if required, perform Karl Fischer and XRPD as part of fit-for-purpose characterization.

Always refer to the product’s CoA/Spec Sheet for authoritative physical data specific to this lot.

Quality and Grades

Item-specific grade and purity are not listed in the Product Data.

  • Item-specific status:

    • Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.
  • Guidance on common grades (general context):

    • Screening/Library grade: Typically suitable for biochemical and cellular screening; often accompanied by LC–MS purity (commonly ≥95% area by a stated method). Verify method details (column, gradient, detection wavelength, and ionization) to match your analytical platform.
    • Analytical/Reference grade: Emphasizes identity and purity confirmation (1H/13C NMR, HRMS, LC–MS) for use as internal/external standards.
    • Inhibitor/probe grade: May include counter-ion specification, residual solvent limits, and stability data in DMSO at various temperatures.
  • What to verify on the CoA for this item:

    • Exact purity metric and methodology (HPLC/UPLC/GC area%, %w/w, UV detection details).
    • Salt form vs free base/acid; water content and residual solvents (if reported).
    • Batch identity data (NMR, HRMS) and storage recommendations consistent with “Store at −20°C.”

If your application requires enhanced purity (e.g., sub-ppm metal content or low UV background), contact us for the most recent lot-specific CoA or discuss custom purification.

Reaction and Applications

The Product Data list NXT629 within a small-molecule/compound library; no specific synthetic or application notes are provided. Accordingly, the following are general research applications and best practices rather than item-specific claims.

  • Typical research uses (general):

    • Screening campaigns: Use as part of chemical probe libraries for target identification, hit validation, or phenotypic screening.
    • Assay development: Evaluate compound stability, solubility, and interference profiles (e.g., auto-fluorescence, redox activity) across assay modalities.
    • Analytical reference: Retention-time marker or LC–MS method development standard when no strong ion suppression is expected.
  • Practical considerations:

    • Establish compound integrity by LC–MS (check for in-source fragmentation/adducts) and re-check after freeze–thaw cycles.
    • Assess PAINS/assay interference risk using cheminformatic filters; perform orthogonal assays.
    • If photolability is suspected, protect from light and avoid high-energy plate readers without controls.
  • Data package recommended before deployment:

    • Identity: 1H/13C NMR, HRMS.
    • Purity: LC–MS/HPLC chromatogram with method specifics.
    • Solubility/stability: DMSO stock stability at −20°C and room-temperature bench stability; aqueous precipitation limits.

Please consult the CoA or contact us for any item-specific application guidance once full structure/solubility details are confirmed.

Reaction Conditions

No reaction chemistry is defined for this catalog entry because NXT629 is offered as a finished small molecule rather than a reagent. In the absence of a known structure, specific conditions (solvents, catalysts, temperatures) cannot be recommended for transformations of this compound.

  • If derivatization is planned (general advice only):

    • Begin with micro-scale experiments (≤5 mg) and monitor by LC–MS.
    • Choose mild conditions first (room temperature, neutral to slightly basic) and escalate only if the compound is stable.
    • Avoid strong oxidants/reductants and extremes of pH until stability is established.
  • Analytical conditions (general, for method development):

    • LC–MS: Water (0.1% formic acid or 5–10 mM ammonium acetate) with acetonitrile gradients; screen ESI+/−.
    • UV–Vis: Record a scan (200–400 nm) to identify absorbance maxima and set detection wavelengths; be aware of potential lack of chromophores.

For any reaction planning, secure the definitive structure and consult primary literature for closely related scaffolds.

Safety and Handling

Safety information specific to this item is not provided in the Product Data and should be obtained from the SDS.

  • Item-specific safety fields:

    • GHS Classification: Not specified for this item; refer to SDS.
    • Signal Word: Not specified for this item; refer to SDS.
    • Hazard (H) Statements: Not specified for this item; refer to SDS.
    • Pictograms: Not specified for this item; refer to SDS.
  • General laboratory precautions (for small organic research compounds; not item-specific):

    • Handle in a fume hood wearing standard PPE: lab coat, safety glasses, and appropriate chemical-resistant gloves. Avoid inhalation of dust/vapors and contact with skin/eyes.
    • Prevent uncontrolled contact with strong oxidizers, strong acids/bases, and ignition sources until specific incompatibilities are known.
    • If supplied as a powder, minimize dust generation; consider antistatic measures and weigh in a ventilated enclosure.
  • First-aid overview (general):

    • Inhalation: Move to fresh air; seek medical attention if symptoms occur.
    • Skin contact: Wash with soap and water; remove contaminated clothing.
    • Eye contact: Rinse cautiously with water for several minutes; seek medical advice if irritation persists.
    • Ingestion: Rinse mouth; do not induce vomiting; seek medical advice.
  • Spill/accidental release (general):

    • Contain and collect with inert absorbent for liquids or dampen and sweep for solids; dispose according to institutional and local regulations.

Always defer to the official SDS for hazard classification and detailed response procedures.

Solvent Selection

No item-specific solubility data are provided. The following is general guidance for dissolving and handling small-molecule library members like NXT629; verify with your own solubility tests.

  • Primary stock solvents (general):

    • DMSO (anhydrous): First-line solvent for assay stocks; aim for 10–50 mM master stocks, filtered (0.2 µm) if compatible.
    • DMF or NMP: Alternatives when DMSO solubility is limited, particularly for highly aromatic or polar–aprotic–preferring compounds.
    • Acetonitrile or methanol: Useful for analytical dilutions and mixed aqueous systems.
  • Aqueous compatibility (general):

    • Prepare working solutions by serial dilution into assay buffer, maintaining final DMSO ≤0.1–1% v/v as required by the biology. For poor aqueous solubility, consider co-solvent blends (MeCN/H2O, MeOH/H2O) or surfactants (e.g., 0.01–0.05% Tween-20) as permitted by your assay.
  • Practical tips:

    • Warm (room temp to 37°C) and vortex/sonicate to assist dissolution; avoid prolonged heating that could degrade sensitive motifs.
    • Document precipitation limits visually and by UV/LC–MS.
    • Use amber vials if the compound is light-sensitive (unknown here; assess experimentally).
  • Comparison snapshot (general):

    • DMSO: broad solubilizer, biologically tolerated in small %.
    • MeCN: LC–MS friendly, mixes well with water, lower viscosity.
    • MeOH/EtOH: good protic options; consider assay tolerance.

Always confirm final solvent composition does not interfere with your assay readout.

Storage and Reconstitution

Item-specific storage and shipping information are provided; reconstitution specifics are not.

  • Item-specific details (from Product Data):

    • Storage Conditions: Store at −20°C.
    • Shipped In: Ice chest + ice pads.
  • General handling and reconstitution guidance (not item-specific):

    • Upon receipt, allow the sealed container to reach room temperature before opening to minimize moisture uptake.
    • If supplied as a solid, prepare a concentrated stock solution in anhydrous DMSO (typical 10–50 mM), vortex/sonicate until fully dissolved, and aliquot into low-dead-volume, amber containers.
    • If supplied in solution, verify solvent composition and concentration on the label/CoA before aliquoting.
    • Avoid repeated freeze–thaw cycles; use single-use aliquots when possible. Record preparation date and lot number on aliquots.
    • Protect from light if photolability is suspected; store in sealed vials with minimal headspace to limit oxidation/evaporation.
  • Stability notes:

    • Long-term stability, water content limits, and peroxide/metal specifications are not provided for this item. For definitive shelf-life and re-test intervals, consult the CoA/Spec Sheet or request stability data.

For any discrepancies between this guidance and your institutional SOPs or the SDS/CoA, follow the SDS/CoA and institutional requirements.

Structure and Identity

Brief overview: NXT629 (SKU N651282) is listed in our small-molecule/compound library collection. Structural identifiers are only partially provided for this catalog entry.

  • Item-specific identifiers (from Product Data):

    • Product Name: NXT629
    • CAS: 1454925-59-7
    • PubChem CID: 71721539
    • InChIKey: 148786 (as provided)
    • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
  • Structure description:

    • A precise 2D/3D structural description cannot be given without a definitive SMILES/InChI. For structure-based work (docking, QSAR, method development), please consult the official Certificate of Analysis (CoA), Spec Sheet, or trusted databases using the provided CAS (1454925-59-7) or CID (71721539).
  • Guidance for identity confirmation (general best practice):

    • Cross-verify CAS and CID across at least two databases (e.g., PubChem and vendor CoA) to ensure the correct tautomer/salt form.
    • If analytical authentication is required, acquire/compare: 1H/13C NMR, HRMS, and, when applicable, LC–MS purity trace and retention time under method conditions.
    • If the compound can exist as multiple stereoisomers or polymorphs (unknown here), clarify configuration/form on the CoA prior to critical experiments.
Synthetic Utility

NXT629 is listed as a discrete small-molecule library member, not as a synthetic building block or reagent. Without a disclosed structure, no item-specific reactivity or functional-group guidance can be provided.

  • General notes (applicability depends on actual structure):

    • If structural information reveals common handles (e.g., aryl halide, boronate, acid/amine), standard cross-coupling or amide-coupling tactics may allow late-stage diversification for SAR.
    • Stability toward bases, acids, nucleophiles/electrophiles, or oxidants must be determined experimentally or from the CoA/structure.
  • Recommendations before any derivatization:

    • Obtain the exact structure and confirm purity/identity.
    • Perform small-scale compatibility tests (e.g., base/acids screening) and monitor by LC–MS to avoid decomposition.

Given the current information, treat NXT629 as an end-use screening compound rather than a synthetic intermediate.

Target Specificity

Item-specific biological target information is not provided in the Product Data for NXT629.

  • Target data provided: None. Any statements about biochemical targets, pathways, or selectivity would be speculative and are therefore omitted.

If you possess internal data identifying the molecular target(s), we recommend documenting:

  • Assay format and conditions used to determine potency (e.g., IC50/Ki/EC50) and replicates.
  • Counter-screen panel and off-target profiling (kinase panel, GPCR panel, etc.).
  • Biophysical confirmation (e.g., CETSA, SPR, ITC, DSF) and, where applicable, structural evidence (co-crystal or cryo-EM).

Please contact us if you wish to append verified target specificity data to this catalog entry.

Foire aux questions

What is the purity of this product?
This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1454925-59-7, the molecular formula is C35H39N5O3S, and the molecular weight is 609.78 g/mol. InChIKey IRSFLNXJVJKMDT-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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