OAC1 - ≥97% , CAS No.300586-90-7

CAS: 300586-90-7 Cat. No.: O129631 Formule: C₁₄H₁₁N₃O Poids moléculaire: 237.26

QUALITÉ & PURETÉ ≥97%

Synonyms

OAC-1 | Oct4-activating Compound 1 | N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

AC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.
An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1

Spécifications

Synonymes

OAC-1 | Oct4-activating Compound 1 | N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide

Spécifications et pureté

≥97%

Mécanismes biochimiques et physiologiques

Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥97%

Noms et identifiants

Pubchem Sid

528766462

Sourires canoniques

C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3

IUPAC Name

N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide

InChIKey

HWJRIFZDXJKJJN-UHFFFAOYSA-N

INCHI

1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)

Isomères SMILES

C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3

WGK Allemagne

3

Poids moléculaire

237.26

Reaxy-Rn

32136747

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32136747&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyrrolopyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyrrolopyridines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolopyridines
• Alternative Parents: Benzamides Benzoyl derivatives Pyridines and derivatives Imidolactams Pyrroles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzamide - Benzoic acid or derivatives - Pyrrolopyridine - Benzoyl - Monocyclic benzene moiety - Pyridine - Benzenoid - Imidolactam - Pyrrole - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrrolopyridines. These are compounds containing a pyrrolopyridine moiety, which consists of a pyrrole ring fused to a pyridine. Pyrrole is 5-membered ring consisting of four carbon atoms and one nitrogen atom. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 23.73, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 23.73, Max Conc. mM: 100
• Sensibilité: Light Sensitive,Air Sensitive,Heat Sensitive
• Indice de réfraction: 1.76
• Point d'ébullition (°C): ~386.6 °C at 760 mmHg
• Point de fusion (°C): 197.05°C
• Poids moléculaire: 237.260 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 237.09 Da
• Monoisotopic Mass: 237.09 Da
• Topological Polar Surface Area: 57.800 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 301.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1