ODN 1668 - ≥99% , CAS No.1186063-66-0

CAS: 1186063-66-0 Cat. No.: O648744 Poids moléculaire: 6364.10

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Vue d’ensemble

ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’

In Vitro

ODN 1668 induces TNF-α secretion and promotes polyclonal B cell activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ODN 1668 (10 nmol) stimulates responses to protein antigen . ODN 1668 (1 or 5 mg/kg; i.p. or s.c.; once) causes moderate fever and anorexia in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BW6 mice Dosage: 10 nmol Administration: 300 μg OVA (ovalbumin) in PBS or liposomes containing OVA were injected with or without 10nmol ODN in the hind footpads of C57BW6 mice. A boost of the same\ninoculum was given at 2 weeks, and 1 week later blood was taken for serum antibody titering. Result: Strongly potentiated the antibody response and induced class switching toward IgG2a and IgG2b. Showed B cell blast formation and a more than twofold increase in B7.2 (CD86) and IL-2 receptor-α (CD25) surface expression. Animal Model: Male Wistar rats with body weights in the range of 175–200 gDosage: 1 mg/kg or 5 mg/kg Administration: Intraperitoneal and subcutaneous injection, once Result: Caused moderate fever and anorexia. Induced a significant increase of IL-6. Increased expression of inflammatory genes and activated inflammatory transcription factors.

Form:Solid

IC50& Target:TLR9

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’.

Conditions de stockage de stockage

Store at -20°C,Desiccated

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

• Poids moléculaire: 6364.10

Propriétés chimiques et physiques

• Solubilité: H2O : ≥ 20 mg/mL (3.14 mM)

Foire aux questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1186063-66-0, and the molecular weight is 6364.10 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.