ODN D-SL03 - ≥99% , CAS No.1198621-85-0

CAS: 1198621-85-0 Cat. No.: O649166 Poids moléculaire: 9345.00

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Vue d’ensemble

ODN D-SL03 is a C class CpG oligonucleotides , can induce stimulate PBMCs to produce high level of IFN-α . ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'

In Vitro

ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL. ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c mice (6-8 weeks; inoculated with 5×10 5 EMT6 cells) Dosage: 25 μg per mouse Administration: Peritumoral injection, six times in one-day interval, for 0-100 days Result: Induced significant inhibition of tumor growth.

Form:Solid

IC50& Target:IFN-α

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

ODN D-SL03 is a C class CpG oligonucleotides , can induce stimulate PBMCs to produce high level of IFN-α . ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets

Conditions de stockage de stockage

Store at -20°C,Desiccated

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

• Sourires canoniques: [DNA, d(P-thio)(T-C-G-C-G-A-A-C-G-T-T-C-G-C-C-G-C-G-T-T-C-G-A-A-C-G-C-G-G)]
• Poids moléculaire: 9345.00

Propriétés chimiques et physiques

• Solubilité: H2O : ≥ 20 mg/mL (2.14 mM)

Foire aux questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1198621-85-0, and the molecular weight is 9345.00 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.