Oxomemazine - ≥99% , CAS No.3689-50-7

CAS: 3689-50-7 Cat. No.: O651500 Formule: C₁₈H₂₂N₂O₂S Poids moléculaire: 330.44 Numéro CE: 222-996-8 PubChem CID: 19396

QUALITÉ & PURETÉ ≥99%

Synonyms

Trimeprazine 5,5-dioxide|(-)-Oxomemazine|Dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine [French]|(+/-)-OXOMEMAZINE|(+)-Oxomemazine|6847 R.P.|Oxomemazinum|10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE, (-)-|Oxomemazina|Oxomemazine (INN)|3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine|Exe-top|Oplex|10-(3-(diMethylaMino)-2-Methylpropyl)-10H-phenothiazine 5,5-dioxide|6847-RP|Doxergan (TN)|6487 RP|Trimeprazine Sulphone; Oxomemazine|Imakol|Oxomemazine [INN:DCF]|OXOMEMAZINE [INN]|10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine-5,5-dioxide|Oxomemazine, (+)-|3-(5,5-dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine|Oxomemazin|OXOMEMAZINE [WHO-DD]|Oxomemazinum [INN-Latin]|3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine #|Doxergan|Oxomemazine, (-)-|Oxymemazine|PHENOTHIAZINE, 10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-, 5,5-DIOXIDE|RP 6847|10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-, 5,5-dioxide, (+)-|Dosegran|OXOMEMAZINE [MART.]|Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, 5,5-dioxide|6487-RP|Dysedon|OXOMEMAZINE [MI]|6847 RP|10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-, 5,5-dioxide, (-)-|10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine 5,5-dioxide|10H-Phenothiazine-10-propanamine, N,N,.beta.-trimethyl-, 5,5-dioxide|Dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine|Oxomemazine|Oxomemazina [INN-Spanish]

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor , displays about 20-fold difference in the affinity for high ( K i = 84 nM, M1 receptor) and low ( K i = 1.65 μM, M2 receptor) affinity sites Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment .

Form:Solid

IC50& Target:H 1 Receptor mGluR 1 84 nM (Ki) mGluR2 1.65 μM (Ki)

Spécifications

Synonymes

Trimeprazine 5,5-dioxide | (-)-Oxomemazine | Dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine [French] | (+/-)-OXOMEMAZINE | (+)-Oxomemazine | 6847 R.P. | Oxomemazinum | 10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE, (-)- | Oxomemazina | Oxomemazine (INN) | 3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethyl Afficher plus

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor , displays about 20-fold difference in the affinity for high ( K i = 84 nM, M1 r

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Pureté

≥99%

Noms et identifiants

Sourires canoniques

CC(CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C31)CN(C)C

IUPAC Name

3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine

InChIKey

QTQPVLDZQVPLGV-UHFFFAOYSA-N

INCHI

1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3

Isomères SMILES

CC(CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C31)CN(C)C

PubChem CID

19396

Poids moléculaire

330.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzothiazines
      • Subclass Phenothiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzothiazines
• Subclass: Phenothiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenothiazines
• Alternative Parents: Alkyldiarylamines Benzenoids 1,4-thiazines Sulfones Trialkylamines Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenothiazine - Alkyldiarylamine - Tertiary aliphatic/aromatic amine - Para-thiazine - Benzenoid - Sulfone - Tertiary amine - Tertiary aliphatic amine - Azacycle - Amine - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (302.63 mM; Need ultrasonic)
• Poids moléculaire: 330.400 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 330.14 Da
• Monoisotopic Mass: 330.14 Da
• Topological Polar Surface Area: 49.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 470.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 3689-50-7, the molecular formula is C18H22N2O2S, and the molecular weight is 330.44 g/mol. InChIKey QTQPVLDZQVPLGV-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.