Perzinfotel - ≥98% , Glutamate [NMDA] receptor antagonist, CAS No.144912-63-0, Glutamate [NMDA] receptor antagonist

CAS: 144912-63-0 Cat. No.: P648963 Formule: C₉H₁₃N₂O₅P Poids moléculaire: 260.18 Numéro CE: 694-536-8 PubChem CID: 6918236

GRADE & PURITY ≥98%

Synonyms

D05447 | LKPOTIIKKKNIQY-UHFFFAOYSA-N | EAA-090 | 2-(dioxo-2,6-diazabicyclo(5.2.0)non-ethyl) phosphonic acid | HY-19168 | DTXSID70162846 | Perzinfotel (USAN/INN) | SCHEMBL371400 | NCGC00487176-01 | DHP, Dicetyl phosphate | BDBM86494 | EAA-090, >=98% (HPLC)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site

In Vitro

Perzinfotel blocks NMDA-induced currents with an IC 50 of 0.48 μM and glutamate-induced neurotoxicity with an IC 50 of 1.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NMDA receptor

Specifications

Synonymes

D05447 | LKPOTIIKKKNIQY-UHFFFAOYSA-N | EAA-090 | 2-(dioxo-2,6-diazabicyclo(5.2.0)non-ethyl) phosphonic acid | HY-19168 | DTXSID70162846 | Perzinfotel (USAN/INN) | SCHEMBL371400 | NCGC00487176-01 | DHP, Dicetyl phosphate | BDBM86494 | EAA-090, >=98% (HPLC)

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Mécanisme d'action

Glutamate [NMDA] receptor antagonist

Pureté

≥98%

Propriétés du produit

• ALogP: -1.6

Noms et identifiants

• Sourires canoniques: C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
• IUPAC Name: 2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethylphosphonic acid
• InChIKey: BDABGOLMYNHHTR-UHFFFAOYSA-N
• INCHI: 1S/C9H13N2O5P/c12-8-6-7(9(8)13)11(3-1-2-10-6)4-5-17(14,15)16/h10H,1-5H2,(H2,14,15,16)
• Isomères SMILES: C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
• WGK Allemagne: 3
• PubChem CID: 6918236
• Poids moléculaire: 260.18

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Amines
        • Level5 Tertiary amines
          • Level6 Tertiary alkylarylamines
            • Level7 Dialkylarylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Tertiary amines - Tertiary alkylarylamines
• Direct Parent: Dialkylarylamines
• Alternative Parents: Secondary alkylarylamines 1,4-diazepines Vinylogous amides Organic phosphonic acids Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Dialkylarylamine - Para-diazepine - Secondary aliphatic/aromatic amine - Organophosphonic acid - Organophosphonic acid derivative - Vinylogous amide - Azacycle - Organoheterocyclic compound - Secondary amine - Organic oxygen compound - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Organic oxide - Organopnictogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO : 20.83 mg/mL (80.06 mM; Need ultrasonic) H2O : 5.88 mg/mL (22.60 mM; ultrasonic and warming and heat to 60°C)
• Poids moléculaire: 260.180 g/mol
• XLogP3: -1.600
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 260.056 Da
• Monoisotopic Mass: 260.056 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 452.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1