PF-04856264 - 10mM in DMSO , CAS No.1235397-05-3

CAS: 1235397-05-3 Cat. No.: P654480 Formule: C₂₀H₁₅N₅O₃S₂ Poids moléculaire: 437.49 Numéro CE: 808-498-9 PubChem CID: 71718072

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC 50 s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect

In Vivo

PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)Dosage: 3, 30 mg/kg Administration: I.p. Result: Significantly reduced spontaneous pain behaviors in mice.

IC50& Target:IC50: 28 (human Nav1.7), 131 nM (mouse Nav1.7), 19 nM (cynomolgus monkey Nav1.7), 42 nM (dog Nav1.7)

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC 50 s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: CN1C(=CC=N1)C2=CC=CC=C2OC3=C(C=C(C=C3)S(=O)(=O)NC4=NC=CS4)C#N
• PubChem CID: 71718072
• Poids moléculaire: 437.49

Cibles associées (humaines)

SCN9A Tclin Sodium channel protein type 9 subunit alpha (6 Activities)

Discover Target: SCN9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1235397-05-3, the molecular formula is C20H15N5O3S2, and the molecular weight is 437.49 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.