10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Vue d’ensemble
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor , with an EC 50 and K i of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease
In Vitro
PF-06256142 exhibits IC 50 values of <5 μM as an antagonist at the following 4 targets: M 1 (4.9 μM); CB1 (2.1 μM); H 1 (4.6 μM); Nav 1.5 (1.1 μM). PF-06256142 has an IC 50 of approximately 12 μM for hERG. PF-06256142 shows a K i of 4.8 nM for D5 exquisitely selective than D2 (K i >10 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg) . PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 5.0 mg/kg for i.v.; 5 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous injection and oral administration Result: Oral bioavailability (85%), T 1/2 (2.3 h).
IC50& Target:Human D 1 Receptor 33 nM (EC 50 )
Specifications
Spécifications et pureté
10mM in DMSO
Mécanismes biochimiques et physiologiques
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor , with an EC 50 and K i of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease.
Conditions de stockage de stockage
Store at -80°C
Expédié en
Dry ice packs + Cold packs
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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Avis
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Foire aux questions
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1609583-14-3, the molecular formula is C21H16N4O2S, and the molecular weight is 388.44 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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