PF-06291874 - 10mM in DMSO , Glukagon receptor antagonist, CAS No.1393124-08-7, Glukagon receptor antagonist

CAS: 1393124-08-7 Cat. No.: P656549 Formule: C₂₆H₂₈F₃N₃O₄ Poids moléculaire: 503.51 PubChem CID: 60151939

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

PF-06291874 is a highly potent, non-peptide and orally active Glukagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).

In Vivo

PF-06291874 exposure is approximately dose-proportional with a half-life of ∼19.7-22.7 h. PF-06291874 has a fast on and off rate. PF-06291874 is highly bound to human plasma protein, with a mean free fraction of ∼0.55%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

PF-06291874 is a highly potent, non-peptide and orally active Glukagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Mécanisme d'action

Glukagon receptor antagonist

Propriétés du produit

• ALogP: 5

Noms et identifiants

• Isomères SMILES: CCC[C@@H](C1=CC=C(C=C1)C(=O)NCCC(=O)O)OC2=CC(=C(C(=C2)C)N3C=C(C=N3)C(F)(F)F)C
• PubChem CID: 60151939
• Poids moléculaire: 503.51

Cibles associées (humaines)

GCGR Tclin Glucagon receptor (1 Activities)

Discover Target: GCGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1393124-08-7, the molecular formula is C26H28F3N3O4, and the molecular weight is 503.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.