PF-06747711 - 10mM in DMSO , CAS No.1892576-58-7

CAS: 1892576-58-7 Cat. No.: P654763 Formule: C₂₆H₂₆F₃N₅O₂ Poids moléculaire: 497.51 PubChem CID: 118977746

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 ( RORC2 , also known as RORγt ) inverse agonist, with an IC 50 of 4.1 nM. Anti-skin inflammatory activity

In Vitro

PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC 50 of 9.5 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8−10 week old female Balb/c mice Dosage: 10, 30, and 100 mg/kg Administration: P.O. daily over 5 days Result: Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg.

IC50& Target:IC50: 4.1 nM (RORC2)

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 ( RORC2 , also known as RORγt ) inverse agonist, with an IC 50 of 4.1 nM. Anti-skin inflammatory activity.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Noms et identifiants

• Isomères SMILES: CC(C)C(=O)N1CCC(CC1)C2=CN(C3=NC=C(C(=C23)C(F)(F)F)NC(=O)C4=CC=CC(=C4)C#N)C
• PubChem CID: 118977746
• Poids moléculaire: 497.51

Cibles associées (humaines)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1892576-58-7, the molecular formula is C26H26F3N5O2, and the molecular weight is 497.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.