PF-4840154 - 10mM in DMSO , CAS No.1332708-14-1

CAS: 1332708-14-1 Cat. No.: P656380 Formule: C₂₆H₃₈N₆O₂ Poids moléculaire: 466.62 PubChem CID: 53380803

QUALITÉ & PURETÉ 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC 50 s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse

In Vivo

PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female CD1 mice (25-30g) (In TrpA1+/+ mice) Dosage: 30 nmol Administration: Intraplantar (i.pl) injection Result: Elicited robust licking behavior.

IC50& Target:IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)

Spécifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC 50 s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

AGONIST

Noms et identifiants

Isomères SMILES

CC(C)CNC1=NC(=NC=C1C(=O)NCC2=CC=CC=C2)N3CCN(CC3)CC4CCCOC4

CAS alternatif

1332708-14-1

PubChem CID

53380803

Termes d'entrée MeSH

PF 4840154;PF-4840154;PF4840154

Poids moléculaire

466.62

Cibles associées (humaines)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (0 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1332708-14-1, the molecular formula is C26H38N6O2, and the molecular weight is 466.62 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.