Name: PF 5006739 - ≥98% , CAS No.1293395-67-1
SKU: P288881
Availability: InStock

PF 5006739 - ≥98% , CAS No.1293395-67-1

CAS: 1293395-67-1 Cat. No.: P288881 Formule: C₂₂H₂₂FN₇O Poids moléculaire: 419.46 Numéro CE: 808-737-7 PubChem CID: 51353555

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PF 5006739 - ≥98% CAS No(1293395-67-1) by Aladdin Scientific

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DISPONIBLE À COMMANDE

GRADE & PURITY ≥98%

Synonyms

4-{4-(4-Fluorophényl)-1-[1-(1,2-Oxazol-3-Ylméthyl)pipéridin-4-Yl]-1h-Imidazol-5-Yl}pyrimidin-2-Amine | PF-5006739 | 2-Pyrimidinamine, 4-[4-(4-fluorophényl)-1-[1-(3-isoxazolylméthyl)-4-pipéridinyl]-1H-imidazol-5-yl]- | PF 5006739

Storage

Stocker à -20°C, chargé d'argon

Shipped In

Glacière + blocs de glace

Vue d’ensemble Specifications Noms et identifiants Documentation Advanced Data Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Calculateurs de solution Avis

🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Stocker à -20°C, chargé d'argon Ships Glacière + blocs de glace Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Vue d’ensemble

Le PF-5006739 est un inhibiteur puissant et sélectif de la CK1δ/ε avec des IC50 de 3,9 nM et 17,0 nM, respectivement. Le PF-5006739 est un agent thérapeutique potentiel pour une série de troubles psychiatriques, avec une faible puissance nanomolaire in vitro pour la CK1δ/ε et une grande sélectivité du kinome. Le PF-5006739 atténue de manière dose-dépendante le comportement de recherche d'agents opioïdes dans un modèle de réintégration opérant chez les rongeurs. Le PF-5006739 améliore la tolérance au glucose dans les modèles d'obésité induite par l'alimentation (DIO) et les modèles génétiques d'obésité (ob/ob) chez la souris.

Specifications

Synonymes

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

otent inhibiteur de la caséine kinase 1δ/ε (les valeurs IC50 sont de 3,9 et 17 nM, respectivement). Médiateur des effets de retard de phase du rythme circadien in vivo. Atténue le comportement de recherche de drogues opioïdes dans les modèles de dépendanc

Conditions de stockage de stockage

Stocker à -20°C, chargé d'argon

Expédié en

Glacière + blocs de glace

Type d'action

INHIBITOR

Pureté

≥98%

Noms et identifiants

Pubchem Sid

528766584

Sourires canoniques

C1CN(CCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F)CC5=NOC=C5

IUPAC Name

4-[5-(4-fluorophenyl)-3-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]imidazol-4-yl]pyrimidin-2-amine

InChIKey

XPWHRQHBPRSUAW-UHFFFAOYSA-N

INCHI

1S/C22H22FN7O/c23-16-3-1-15(2-4-16)20-21(19-5-9-25-22(24)27-19)30(14-26-20)18-6-10-29(11-7-18)13-17-8-12-31-28-17/h1-5,8-9,12,14,18H,6-7,10-11,13H2,(H2,24,25,27)

Isomères SMILES

C1CN(CCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F)CC5=NOC=C5

PubChem CID

51353555

Poids moléculaire

419.46

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Classe Azoles
    - Subclass Imidazoles
      - Level5 Substituted imidazoles
        Level6 Phenylimidazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Classe	Azoles
Subclass	Imidazoles
Intermediate Tree Nodes	Substituted imidazoles
Direct Parent	Phenylimidazoles
Alternative Parents	Fluorobenzenes Aralkylamines Aminopyrimidines and derivatives Piperidines N-substituted imidazoles Aryl fluorides Isoxazoles Heteroaromatic compounds Trialkylamines Oxacyclic compounds Azacyclic compounds Primary amines Organooxygen compounds Organofluorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	5-phenylimidazole - 4-phenylimidazole - Aminopyrimidine - Fluorobenzene - Halobenzene - Aralkylamine - Aryl halide - Monocyclic benzene moiety - N-substituted imidazole - Piperidine - Pyrimidine - Benzenoid - Aryl fluoride - Isoxazole - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Oxacycle - Azacycle - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Primary amine - Hydrocarbon derivative - Amine - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Structure 3D

Cibles associées (humaines)

CSNK1D Tchem Casein kinase I isoform delta (1 Activities)

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1E Tclin Casein kinase I isoform epsilon (1 Activities)

Discover Target: CSNK1E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1D Tchem Casein kinase I delta (4546 Activities)

Discover Target: CSNK1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1E Tclin Casein kinase I epsilon (1412 Activities)

Discover Target: CSNK1E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)

Discover Target: CDK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

Discover Target: AURKA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)

Discover Target: TRIM24

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRPF1 Tchem Peregrin (2217 Activities)

Discover Target: BRPF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

Discover Target: Fgfr3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Article
J2411779	Certificate of Analysis	Jul 06, 2024	P288881
J2411780	Certificate of Analysis	Jul 06, 2024	P288881
J2411781	Certificate of Analysis	Jul 06, 2024	P288881
J2411782	Certificate of Analysis	Jul 06, 2024	P288881
J2411783	Certificate of Analysis	Jul 06, 2024	P288881
J2411784	Certificate of Analysis	Jul 06, 2024	P288881
J2411785	Certificate of Analysis	Jul 06, 2024	P288881
J2411786	Certificate of Analysis	Jul 06, 2024	P288881

Propriétés chimiques et physiques

Solubilité	Solvent:DMSO, Max Conc. mg/mL: 41.95, Max Conc. mM: 100
Sensibilité	moisture & light sensitive
Poids moléculaire	419.500 g/mol
XLogP3	1.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	419.187 Da
Monoisotopic Mass	419.187 Da
Topological Polar Surface Area	98.900 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	570.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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