PFK15 - Moligand™, 10mM in DMSO , Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3, CAS No.4382-63-2, Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

CAS: 4382-63-2 Cat. No.: P407887 Formule: C₁₇H₁₂N₂O Poids moléculaire: 260.29 Numéro CE: 809-326-5 PubChem CID: 25142799

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
In vitro

PFK15 produces potent growth inhibition in a series of cancer cells. In Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells, PFK15 also reduces F26BP, glucose uptake, and intracellular ATP level.

In vivo

In vivo, PFK15 has adequate pharmacokinetic properties. PFK15 (25 mg/kg i.p.) suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three human xenograft models of cancer in athymic mice, PFK15 also yields antitumor effects that are comparable to approved chemotherapeutic agents.
Cell Data

cell lines：

Concentrations：~30 μM

Incubation Time：48 hours

Powder Purity:≥99%

Specifications

Synonymes

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

Noms et identifiants

• Isomères SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
• WGK Allemagne: 3
• CAS alternatif: 4382-63-2
• PubChem CID: 25142799
• Termes d'entrée MeSH: 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK15
• Poids moléculaire: 260.29

Cibles associées (humaines)

PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1 Activities)

Discover Target: PFKFB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)