Polydatine - ≥95%(HPLC) , CAS No.27208-80-6

CAS: 27208-80-6 Cat. No.: P109978 Formule: C₂₀H₂₂O₈ Poids moléculaire: 390.39 Beilstein Registry Number: 17(4)3001 Numéro CE: 111-790-2

GRADE & PURITY ≥95%(HPLC)

Synonyms

Piceid | Resveratrol 3-Glucoside | 4',5-Dihydroxystilben-3-yl β-D-Glucopyranoside

Storage

A conserver entre 2 et 8°C

Shipped In

Glace humide

Vue d’ensemble

La polydatine est le glycoside du resvératrol isolé à l'origine de l'herbe chinoise Polygonum cuspidatum. Il a été démontré que ce composé inhibe l'agrégation plaquettaire et augmente les rapports LDL-C/HDL-C et TC/HDL-C. Des études portant sur les cellules myocardiques, les globules blancs, les cellules musculaires lisses vasculaires et les cellules endothéliales indiquent que la polydatine peut inhiber l'expression de l'ICAM-1, augmenter le Ca2+, affaiblir l'adhésion entre les globules blancs et les cellules endothéliales et activer les canaux KATP.
La polydatine, un type de phytoalexine polyphénolique, a de nombreux effets physiologiques et pharmacologiques, notamment des activités anti-inflammatoires et anti-oxydantes.

Specifications

Synonymes

Piceid | Resveratrol 3-Glucoside | 4',5-Dihydroxystilben-3-yl β-D-Glucopyranoside

Spécifications et pureté

≥95%(HPLC)

Mécanismes biochimiques et physiologiques

Stilbène présent dans les herbes médicinales. Antioxydant, anti-inflammatoire et neuroprotecteur, il inhibe l'ICAM1 et le NF-kB induits par le LPS. Précurseur du resvératrol et dérivé du dihydroresvératrol (Asc 2862). Anti-inflammatoire, anti-ischémique,

Conditions de stockage de stockage

A conserver entre 2 et 8°C

Expédié en

Glace humide

Type d'action

ACTIVATOR

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥95%(HPLC)

Noms et identifiants

Pubchem Sid

504763382

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763382

Sourires canoniques

C1=CC(=CC=C1C=CC2=CC(=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O

IUPAC Name

(2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

InChIKey

HSTZMXCBWJGKHG-CUYWLFDKSA-N

INCHI

1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1

Isomères SMILES

C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O

CAS alternatif

65914-17-2

Poids moléculaire

390.39

Beilstein

17(4)3001

Reaxy-Rn

1604738

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1604738&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Classe Stilbenes
      • Subclass Stilbene glycosides

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Classe: Stilbenes
• Subclass: Stilbene glycosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Stilbene glycosides
• Alternative Parents: Phenolic glycosides Hexoses O-glycosyl compounds Styrenes Phenoxy compounds Phenol ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Oxanes Secondary alcohols Polyols Oxacyclic compounds Acetals Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Stilbene glycoside - Phenolic glycoside - Hexose monosaccharide - Glycosyl compound - O-glycosyl compound - Phenoxy compound - Styrene - Phenol ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Monosaccharide - Benzenoid - Oxane - Secondary alcohol - Acetal - Oxacycle - Organoheterocyclic compound - Polyol - Alcohol - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as stilbene glycosides. These are compounds structurally characterized by the presence of a carbohydrate moiety glycosidically linked to the stilbene skeleton.
• External Descriptors: Diphenyl ethers, biphenyls, dibenzyls and stilbenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water (<1 mg/ml at 25 °C), DMSO (78 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and ethyl acetate.
• Sensibilité: Heat sensitive
• Rotation spécifique [α]: -54 ° (C=1, Acetone)
• Point de fusion (°C): 223-226°C
• Poids moléculaire: 390.400 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 390.131 Da
• Monoisotopic Mass: 390.131 Da
• Topological Polar Surface Area: 140.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 506.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1