Pomalidomide-PEG₆-CO₂H - ≥98% , CAS No.2225148-49-0

CAS: 2225148-49-0 Cat. No.: P486908 Formule: C₂₈H₃₉N₃O₁₂ Poids moléculaire: 609.62 PubChem CID: 139034004

GRADE & PURITY ≥98%

Synonyms

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Description

Protein degrader builiding block Pomalidomide-PEG6-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Synonymes

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Spécifications et pureté

≥98%

Conditions de stockage de stockage

Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 504773551
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773551
• Sourires canoniques: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCOCCC(=O)O
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChIKey: NBDBXIANAMQQQU-UHFFFAOYSA-N
• INCHI: 1S/C28H39N3O12/c32-23-5-4-22(26(35)30-23)31-27(36)20-2-1-3-21(25(20)28(31)37)29-7-9-39-11-13-41-15-17-43-19-18-42-16-14-40-12-10-38-8-6-24(33)34/h1-3,22,29H,4-19H2,(H,33,34)(H,30,32,35)
• PubChem CID: 139034004
• Poids moléculaire: 609.62

Propriétés chimiques et physiques

• Sensibilité: Moisture sensitive
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable