Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process,and exerts a variety of potent protective pharmacological effects on diabetic complications.

Specifications

Synonyms

Specifications & Purity

analytical standard

Biochemical and Physiological Mechanisms

Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process, and exerts a variety of potent protective pharmacological effects on diabetic complications. In vitro: Procyanidin B2 treatment decrease

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Analytical standard

Names and Identifiers

Canonical Smiles	C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
IUPAC Name	(2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
InChIKey	XFZJEEAOWLFHDH-NFJBMHMQSA-N
INCHI	1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26-,27-,28-,29-/m1/s1
Isomeric SMILES	C1[C@H]([C@H](OC2=C1C(=CC(=C2[C@@H]3[C@H]([C@H](OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
PubChem CID	122738
Molecular Weight	578.52

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Flavonoids
    - Subclass Biflavonoids and polyflavonoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Flavonoids
Subclass	Biflavonoids and polyflavonoids
Intermediate Tree Nodes	Not available
Direct Parent	Biflavonoids and polyflavonoids
Alternative Parents	B-type proanthocyanidins Catechins 3'-hydroxyflavonoids 3-hydroxyflavonoids 4'-hydroxyflavonoids 5-hydroxyflavonoids 7-hydroxyflavonoids 1-benzopyrans Catechols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Benzene and substituted derivatives Secondary alcohols Oxacyclic compounds Polyols Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	B-type proanthocyanidin - Bi- and polyflavonoid skeleton - Proanthocyanidin - Catechin - Flavan-3-ol - Hydroxyflavonoid - 3'-hydroxyflavonoid - 7-hydroxyflavonoid - 5-hydroxyflavonoid - 4'-hydroxyflavonoid - 3-hydroxyflavonoid - Flavan - Chromane - 1-benzopyran - Benzopyran - Catechol - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Polyol - Organoheterocyclic compound - Oxacycle - Ether - Hydrocarbon derivative - Alcohol - Organic oxygen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as biflavonoids and polyflavonoids. These are organic compounds containing at least two flavan/flavone units. These units are usually linked through CC or C-O-C bonds. Some examples include C2-O-C3, C2-O-C4, C3'-C3''', and C6-C8''.
External Descriptors	Proanthocyanidins
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-8 (3484 Activities)

Lot Number	Certificate Type	Date	Item
D1816171	Certificate of Analysis	Jul 09, 2025	P133625
D1816170	Certificate of Analysis	Jul 09, 2025	P133625

Refractive Index	1.8
Boil Point(°C)	955.32° C
Melt Point(°C)	197-198°C
Molecular Weight	578.500 g/mol
XLogP3	2.400
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	3
Exact Mass	578.142 Da
Monoisotopic Mass	578.142 Da
Topological Polar Surface Area	221.000 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	925.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

1. Lei He, Qian Hu, Jiukai Zhang, Ranran Xing, Yongsheng Zhao, Ning Yu, Ying Chen. (2023) An integrated untargeted metabolomic approach reveals the quality characteristics of black soybeans from different geographical origins in China. FOOD RESEARCH INTERNATIONAL, [PMID:37254343] [10.1016/j.foodres.2023.112908]
2. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen. (2023) Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach. FOOD CHEMISTRY, [PMID:37141754] [10.1016/j.foodchem.2023.136231]
3. Su Xuexia, Bai Cuihua, Wang Xianghe, Liu Huilin, Zhu Yongcong, Wei Leping, Cui Zixiao, Yao Lixian. (2022) Potassium Sulfate Spray Promotes Fruit Color Preference via Regulation of Pigment Profile in Litchi Pericarp. Frontiers in Plant Science, [PMID:35774808] [10.3389/fpls.2022.925609]
4. Yuting Fan, Qingyu He, Chao Gan, Zhen Wen, Jiang Yi. (2022) Investigation of binding interaction between bovine α-lactalbumin and procyanidin B2 by spectroscopic methods and molecular docking. FOOD CHEMISTRY, [PMID:35217463] [10.1016/j.foodchem.2022.132509]
5. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai. (2021) Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2. MICROCHIMICA ACTA, 188 (1): (1-12). [PMID:33403455] [10.1007/s00604-020-04693-x]
6. Taotao Dai, Jun Chen, David Julian McClements, Ti Li, Chengmei Liu. (2019) Investigation the interaction between procyanidin dimer and α-glucosidase: Spectroscopic analyses and molecular docking simulation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:30794902] [10.1016/j.ijbiomac.2019.02.105]
7. Qian Li, Chengmei Liu, Ti Li, David Julian McClements, Yinxin Fu, Jiyan Liu. (2018) Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels. FOOD RESEARCH INTERNATIONAL, [PMID:30195524] [10.1016/j.foodres.2018.07.006]
8. Jie Zheng, Yu-yan An, Xin-xin Feng, Liang-ju Wang. (2017) Rhizospheric application with 5-aminolevulinic acid improves coloration and quality in ‘Fuji’ apples. SCIENTIA HORTICULTURAE, [PMID:] [10.1016/j.scienta.2017.06.004]
9. Yi-Long Ma, Zi-Tong Wang, Dong-Mei Yang, Zhi Li, Qian-Lan Wu, Xin Guo, Ya-Fang Shang, Kiran Thakur, Zhao-Jun Wei. (2024) Effect of processing and simulated digestion on phenolics, antioxidant and hypoglycemic potential of winter jujube. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2024.116944]
10. Jin Peng, Xu Huiting, Guo Yongjun, Liu Silin, Bai Cuihua, Cao Laixin, Yao Lixian. (2025) The Sprays of Nanoparticles of Zinc Oxide and Titanium Dioxide Enhance Fruit Coloration in Litchi. JOURNAL OF PLANT GROWTH REGULATION, [PMID:] [10.1007/s00344-025-11792-7]
11. Yu Chang, Bowei Zhang, Yuze Jia, Xiaolu Shi, Yingshuang Lu, Fan Wei, Yunhui Zhang, Huan Lv, Lu Dong, Yan Zhang, Xiangwei Tang, Shuo Wang. (2025) Effects of dietary polyphenols addition and oxygen concentration on digestion and absorption of fat in roast beef patties. FOOD CHEMISTRY, [PMID:40222130] [10.1016/j.foodchem.2025.144280]
12. Mengru Li, Wei Zhang, Yuan Huang, Xiaoying Zhang, Wuernisha Kadeer, Leihong Mao, Yuqian Jiang, Rong Tsao, Yao Tang. (2025) Unravelling the migration of bioactive and volatile compounds coupled with water sublimation from grapes to recovered water during dynamic freeze-drying. FOOD CHEMISTRY, [PMID:41075660] [10.1016/j.foodchem.2025.146536]
13. Jingjing Liu, Yan Zhang, Hongwei Yu, Weijia Li, Longfei Li, Yizhou Chen, Shikun Liu, Lixin Qiao, Jiale Kuang, Zetao Chen, Shuang Li, Qingjun Liu. (2026) In-vitro tongue-inspired hydrogel sensor for wine astringency evaluation. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2026.117425]
14. Xueqiang Deng, Zhiqiang Li, Xuan Yi, Dong Ruan, Xiang Chen, Jun Luo. (2026) Calcium-Polyphenol Functionalized Black Phosphorus Nanosheet System for Osteoporosis Therapy via Macrophage Reprogramming and Bone Microenvironment Remodeling. Advanced Healthcare Materials, [PMID:] [10.1002/adhm.202504217]
15. Wenli Tang, Daiwen Zhu, Qilong Zeng, Huan Zhong. (2026) Rice Cultivation Reshapes Mercury Accumulation in Soil-Plant Systems. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:] [10.1021/acs.est.5c16234]
16. Danfei Liu, Yuyang Chen, Xiaoxuan Li, Wenxuan Zhou, Changfan Zhang. (2026) Multifunctional Indicator Films of Polyvinyl Alcohol/Guar Gum (Anthocyanins and Houttuynia Essential Oil Pickering Emulsion) Aided by Residual Networks for Monitoring Pork Freshness. Journal of Future Foods, [PMID:] [10.1016/j.jfutfo.2026.03.018]

ProcyanidinB2 - analytical standard , CAS No.29106-49-8

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

Need help choosing the grade?

View related series

Related Products