PSB-12379 - 10mM in Water , CAS No.1802226-78-3

CAS: 1802226-78-3 Cat. No.: P655974 Formule: C₁₈H₂₃N₅O₉P₂ Poids moléculaire: 515.35 PubChem CID: 122207761

GRADE & PURITY 10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase ( CD73 ) inhibitor with K i s of 9.03 nM (rat) and 2.21 nM (human)

In Vitro

Metabolism : Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)

Specifications

Spécifications et pureté

10mM in Water

Mécanismes biochimiques et physiologiques

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase ( CD73 ) inhibitor with K i s of 9.03 nM (rat) and 2.21 nM (human).

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: C1=CC=C(C=C1)CNC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(CP(=O)(O)O)O)O)O
• PubChem CID: 122207761
• Poids moléculaire: 515.35

Cibles associées (humaines)

NT5E Tchem 5'-nucleotidase (1 Activities)

Discover Target: NT5E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1802226-78-3, the molecular formula is C18H23N5O9P2, and the molecular weight is 515.35 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.