RapaLink-1 - Moligand™, 10 mM in DMSO , CAS No.1887095-82-0

CAS: 1887095-82-0 Cat. No.: R1494482 Molecular Weight: 1784.1 PubChem CID: 145708103

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (HY-13328, a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR . RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1 . RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy . Anticancer activity .

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• PubChem CID: 145708103
• MeSH Entry Terms: 40-O-(2-((1-(32-(4-amino-3-(2-aminobenzo(d)oxazol-5-yl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)-27-oxo-3,6,9,12,15,18,21,24-octaoxa-28-azadotriacontyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)-rapamycin;RapaLink-1
• Molecular Weight: 1784.1