Rasarfin - ≥98% , CAS No.674359-73-0

CAS: 674359-73-0 Cat. No.: R650839 Formule: C₂₃H₂₄ClN₃O₃ Poids moléculaire: 425.91

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Rasarfin is a dual Ras and ARF6 inhibitor.

In Vitro

Rasarfin potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation. ?\nRasarfin blocks GPCR internalization through inhibition of ARF6. ?\nRasarfin treatment results in a dose-dependent reduction in MDA-MB-231 cells. ?\nRasarfin inhibits the recruitment of the clathrin adaptor AP-2 to β-arrestin2 and receptor internalization, both processes that require active ARF6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Rasarfin is a dual Ras and ARF6 inhibitor.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

Sourires canoniques

O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=C(N4CCN(CC4)C(C(C)C)=O)C(Cl)=C3

Poids moléculaire

425.91

Propriétés chimiques et physiques

• Solubilité: DMSO : 50 mg/mL (117.40 mM; ultrasonic and warming and heat to 60°C)