Rasarfin - 10mM in DMSO , CAS No.674359-73-0

CAS: 674359-73-0 Cat. No.: R656426 Formule: C₂₃H₂₄ClN₃O₃ Poids moléculaire: 425.91

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Rasarfin is a dual Ras and ARF6 inhibitor.

In Vitro

Rasarfin potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation. ?\nRasarfin blocks GPCR internalization through inhibition of ARF6. ?\nRasarfin treatment results in a dose-dependent reduction in MDA-MB-231 cells. ?\nRasarfin inhibits the recruitment of the clathrin adaptor AP-2 to β-arrestin2 and receptor internalization, both processes that require active ARF6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Rasarfin is a dual Ras and ARF6 inhibitor.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Poids moléculaire: 425.91