Raxatrigine - 10mM in DMSO , Sodium channel protein type IX alpha subunit blocker, CAS No.934240-30-9, Sodium channel protein type IX alpha subunit blocker

CAS: 934240-30-9 Cat. No.: R655836 Formule: C₁₈H₁₉FN₂O₂ Poids moléculaire: 314.4 PubChem CID: 16046068

QUALITÉ & PURETÉ 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor .

In Vitro

Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the US Food and Drug Administration in July 2013. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Sodium channel blocker

Spécifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor .

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

BLOCKER

Mécanisme d'action

Sodium channel protein type IX alpha subunit blocker

Propriétés du produit

ALogP

2.4

Noms et identifiants

Isomères SMILES

C1C[C@H](N[C@H]1C2=CC=C(C=C2)OCC3=CC=CC=C3F)C(=O)N

CAS alternatif

934240-30-9

PubChem CID

16046068

Termes d'entrée MeSH

BIIB074;CNV1014802;raxatrigine;vixotrigine

Poids moléculaire

314.4

Cibles associées (humaines)

SCN10A Tclin Sodium channel protein type 10 subunit alpha (1 Activities)

Discover Target: SCN10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN4A Tclin Sodium channel protein type 4 subunit alpha (1 Activities)

Discover Target: SCN4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)