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RBN-3143 - 10mM in DMSO , CAS No.2360853-16-1
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC 50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation
In Vivo
RBN-3143 (5 μg; intranasal administration) can improve steroid-resistant asthma mouse models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse of asthma models Dosage: 5 ug Administration: Intranasal administration Result: Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
IC50& Target:PARP14 4 nM (IC 50 ) PARP10 1600 nM (IC 50 ) PARP15 4200 nM (IC 50 ) PARP4 42700 nM (IC 50 ) PARP3 >100000 nM (IC 50 ) PARP2 >100000 nM (IC 50 ) PARP1 >100000 nM (IC 50 )
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC 50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
| Molecular Weight | 449.54 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
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Look up COA →🔬 Specification Sheet
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Certificates（CoA,COO,BSE/TSE and Analysis Chart)
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