RK-33 - 10mM in DMSO , CAS No.1070773-09-9

CAS: 1070773-09-9 Cat. No.: R408134 Formule: C₂₃H₂₀N₆O₃ Poids moléculaire: 428.44 PubChem CID: 46184988

GRADE & PURITY 10mM in DMSO

Synonyms

2H-​Diimidazo[4,​5-​d:4',​5'-​f]​[1,​3]​diazepin-​2-​one, 3,​7-​dihydro-​3,​7-​bis[(4-​methoxyphenyl)​methyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
In vitro

RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity.

In vivo

RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes.
Cell Data

cell lines：

Concentrations：7.5 μM

Incubation Time：12 h

Powder Purity:≥99%

Specifications

Synonymes

2H-​Diimidazo[4,​5-​d:4',​5'-​f]​[1,​3]​diazepin-​2-​one, 3,​7-​dihydro-​3,​7-​bis[(4-​methoxyphenyl)​methyl]​-

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Propriétés du produit

ALogP

2.687

Liaison rotative

6

Noms et identifiants

Isomères SMILES

COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC

PubChem CID

46184988

Poids moléculaire

428.44

Propriétés chimiques et physiques

• DMSO (mg/mL) Solubilité maximale: 85
• DMSO (mM) Solubilité maximale: 198.3941742
• Eau (mg/mL) Solubilité maximale: ＜1

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1070773-09-9, the molecular formula is C23H20N6O3, and the molecular weight is 428.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.