RSVA 405 - ≥98%(HPLC) , CAS No.140405-36-3

CAS: 140405-36-3 Cat. No.: R286690 Formule: C₁₇H₂₀N₄O₂ Poids moléculaire: 312.37 Numéro CE: 167-403-2 PubChem CID: 135400298

QUALITÉ & PURETÉ ≥98%(HPLC)

Synonyms

2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

product description：

RSVA 405, an analog of resveratol, is an activator of AMPK with EC50 of 1 μM and an inhibitor of acetyl-CoA carboxylase (ACC).

Spécifications

Synonymes

2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid

Spécifications et pureté

≥98%(HPLC)

Mécanismes biochimiques et physiologiques

AMP-activated protein kinase (AMPK) activator (EC50= 1μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50= 0.5μM). Induces autophagy and promotes Aβdegradationin vitro. Also inhibits a

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ACTIVATOR

Pureté

≥98%(HPLC)

Noms et identifiants

Pubchem Sid

504773254

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773254

Sourires canoniques

CCN(CC)C1=CC(=C(C=C1)C=NNC(=O)C2=CC=NC=C2)O

IUPAC Name

N-[(E)-[4-(diethylamino)-2-hydroxyphenyl]methylideneamino]pyridine-4-carboxamide

InChIKey

GWQPCBPAOAFXSJ-XDHOZWIPSA-N

INCHI

1S/C17H20N4O2/c1-3-21(4-2)15-6-5-14(16(22)11-15)12-19-20-17(23)13-7-9-18-10-8-13/h5-12,22H,3-4H2,1-2H3,(H,20,23)/b19-12+

Isomères SMILES

CCN(CC)C1=CC(=C(C=C1)/C=N/NC(=O)C2=CC=NC=C2)O

PubChem CID

135400298

Poids moléculaire

312.37

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinecarboxylic acids and derivatives
• Alternative Parents: Phenylalkylamines Aniline and substituted anilines Phenoxides Heteroaromatic compounds Carboxylic acids and derivatives Azacyclic compounds Organooxygen compounds Organic zwitterions Organic salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridine carboxylic acid or derivatives - Aniline or substituted anilines - Phenylalkylamine - Phenoxide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxylic acid derivative - Azacycle - Hydrocarbon derivative - Organic zwitterion - Organic oxide - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Amine - Organic nitrogen compound - Organic salt - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (non humaines)

Trypanosoma brucei brucei (13300 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 15.62, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 1.56, Max Conc. mM: 5；<15.62mg/ml in DMSO;insoluble in ethanol
• Poids moléculaire: 312.370 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 312.159 Da
• Monoisotopic Mass: 312.159 Da
• Topological Polar Surface Area: 77.800 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 392.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1