SB-633825 - 10mM in DMSO , CAS No.956613-01-7

CAS: 956613-01-7 Cat. No.: S655218 Formule: C₂₈H₂₅N₃O₃S Poids moléculaire: 483.58 PubChem CID: 44433173

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

SB-633825 is a potent and ATP-competitive inhibitor of TIE2 , LOK (STK10) and BRK with IC 50 s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis

In Vitro

SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6). SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Tie2 3.5 nM (IC 50 )

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

SB-633825 is a potent and ATP-competitive inhibitor of TIE2 , LOK (STK10) and BRK with IC 50 s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

Isomères SMILES

CC1=C(C=CC(=C1)S(=O)(=O)C)C2=NC(=C(N2C)C3=CC4=C(C=C3)C=C(C=C4)OC)C5=CC=NC=C5

PubChem CID

44433173

Poids moléculaire

483.58