Semzuvolimab (anti-CD4) - Anticorps primaire, specific to CD4, Human IgG1, INHIBITOR of T-cell surface antigen CD4 inhibitor, INHIBITOR of T-cell surface antigen CD4 inhibitor

CAS: 2409099-32-5 Cat. No.: Ab182802

QUALITÉ & PURETÉ Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Humain

Reactive species

Humain

Isotype

Human IgG1

Conjugation

Unconjugated

Vue d’ensemble

Semzuvolimab (anti-CD4) is a murine IgG1κ antibody, targeting to p55, T cell surface antigen T4/Leu-3 (CD4). Murine CD4 antibodies can neutralize HIV infection and have the potential to inhibit HAART stable HIV infection.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Spécifications

Product Name

Semzuvolimab (anti-CD4) - Anticorps primaire, specific to CD4, Human IgG1, INHIBITOR of T-cell surface antigen CD4 inhibitor

Synonymes

CD 4 antibody | CD4 (L3T4) antibody | CD4 antibody | CD4 antigen (p55) antibody | CD4 antigen antibody | CD4 molecule antibody | CD4 receptor antibody | CD4+ Lymphocyte deficiency, included antibody | CD4_HUMAN antibody | CD4mut antibody | L3T4 antibody |

Spécifications et pureté

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Espèce hôte

Humain

Spécificité

CD4

Conjugation

Unconjugated

Grade

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Type d'action

INHIBITOR

Mécanisme d'action

INHIBITOR of T-cell surface antigen CD4 inhibitor

Isotype

Human IgG1

Type de chaîne lumineuse

kappa

SDS-PAGE

27.4 kDa (Light Chain) & 53.6 kDa (Heavy Chain), under reducing conditions; 200.0 kDa, under non-reducing conditions.

Méthode de purification

Protein A purified

Concentration

See COA

CAS

2409099-32-5

Product Line

Produits biologiques

Stockage et expédition

Forme

Liquid

Conditions de stockage de stockage

Store at -80°C,Avoid repeated freezing and thawing

Expédié en

Dry ice packs + Cold packs

Stabilité et stockage

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 with Semzuvolimab (anti-CD4) (Ab182802) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of THP-1 cells labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - ELISA
Immobilized Recombinant Human CD4 protein (rp175911) at 1.0 μg/mL can bind Semzuvolimab (anti-CD4) (Ab182802) with the EC₅₀ of 54.16 ng/mL.

SEC: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - SEC
The purity of Semzuvolimab (anti-CD4) (Ab182802) is more than 95% verified by HPLC.

Cibles associées (humaines)

CD4 Tclin T-cell surface glycoprotein CD4 (0 Activities)

Discover Target: CD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mécanismes d'action

Foire aux questions

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2409099-32-5.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Semzuvolimab (anti-CD4)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.