SETDB1-TTD-IN-1 - ≥99% , CAS No.2755823-12-0

CAS: 2755823-12-0 Cat. No.: S649007 Formule: C₂₈H₃₁N₅O₂ Poids moléculaire: 469.58

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Vue d’ensemble

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) , with a K d of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD

In Vitro

SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with K d s of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (K d >100 μM). ?\nSETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells. ?\nSETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:SETDB1/KMT2G

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) , with a K d of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Argon charged

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

• Sourires canoniques: CN1C[C@@H](C2=CC=C(OCC3=CC=CC=C3)C=C2)C[C@@H](NC4=NC5=C(C(N4CC=C)=O)NC=C5)C1
• Poids moléculaire: 469.58

Propriétés chimiques et physiques

• Solubilité: DMSO : 125 mg/mL (266.20 mM; Need ultrasonic)