Siomycin A - Moligand™,≥85% , CAS No.12656-09-6

CAS: 12656-09-6 Cat. No.: S329546 Formule: C₇₁H₈₁N₁₉O₁₈S₅ Poids moléculaire: 1648.9 PubChem CID: 16130049

GRADE & PURITY Moligand™, ≥85%

Synonyms

Mutabilycin | Sporangiomycin | Antibiotic 6741-21 | Mutabillicin

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Siomycin A, an antibiotic thiazole compound, has been shown to down-regulate the mRNA and protein abundance as well as transcriptional activity of transcription factor forkhead box M1 (FoxM1). Consequentially, it was demonstrated that the downstream target genes of FoxM1, such as CENP-B, Survivin, and Cdc25B were repressed. This compound was also reported to induce potent p53-independent apoptosis in cancer cell lines of different origin. Siomycin A is an inhibitor of FOXM1.

Application

Siomycin A from Streptomyces sioyaensis yields clear, colorless to faint yellow solution in DMSO at 10 mg/ml.

Siomycin A from Streptomyces sioyaensis may be used in cell signaling studies.

Siomycin A has been used as a forkhead box protein M1 (FOXM1) inhibitor to study the effect of pharmacological inhibition of FOXM1 on isocitrate dehydrogenases 1 (IDH1) protein levels.

Specifications

Synonymes

Mutabilycin | Sporangiomycin | Antibiotic 6741-21 | Mutabillicin

Spécifications et pureté

Moligand™,≥85%

Mécanismes biochimiques et physiologiques

Siomycin A is a macrocyclic antibiotic with potent and selective antibacterial activity against gram negative and gram positive bacteria, including Mcobacterium tuberculosis and other clinical resistant strains. Siomycin inhibits antibody production and a

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Pureté

≥85%

Noms et identifiants

• Pubchem Sid: 504768054
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768054
• Sourires canoniques: CC=C1C2=NC(CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC4C(OC(=O)C5=NC6=C(C=CC(C6O)NC(C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C(=O)NC7(CCC(=NC7C8=CSC4=N8)C9=NC(=CS9)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C2=NC(=CS2)C(=O)NC(C(=O)N1)C(C)O)C)C(C)C)C(=C5)C(C)O)C)C(C)(C(C)O)O
• IUPAC Name: N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide
• InChIKey: AKFVOKPQHFBYCA-UHFFFAOYSA-N
• INCHI: 1S/C71H81N19O18S5/c1-14-37-64-83-44(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-43(23-112-67)59(101)88-48-33(11)108-68(106)40-19-36(31(9)91)35-15-16-38(50(94)49(35)79-40)78-46(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-45(24-113-69)60(102)87-47(32(10)92)63(105)81-37)18-17-39(80-51(71)41-20-111-66(48)82-41)65-84-42(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-16,19-21,23-25,30-34,38,44,46-48,50-52,78,91-94,107H,4-7,17-18,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99)
• Isomères SMILES: CC=C1C2=NC(CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC4C(OC(=O)C5=NC6=C(C=CC(C6O)NC(C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C(=O)NC7(CCC(=NC7C8=CSC4=N8)C9=NC(=CS9)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C2=NC(=CS2)C(=O)NC(C(=O)N1)C(C)O)C)C(C)C)C(=C5)C(C)O)C)C(C)(C(C)O)O
• WGK Allemagne: 3
• PubChem CID: 16130049
• Poids moléculaire: 1648.9

Propriétés chimiques et physiques

• Solubilité: DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water.

Foire aux questions

What is the purity of this product?

This product is supplied at ≥85% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 12656-09-6, the molecular formula is C71H81N19O18S5, and the molecular weight is 1648.9 g/mol. InChIKey AKFVOKPQHFBYCA-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.