SKA 121 - Moligand™, ≥98%(HPLC) , Activator of K Ca3.1, CAS No.1820708-73-3, Activator of K Ca3.1

CAS: 1820708-73-3 Cat. No.: S287446 Formule: C₁₂H₁₀N₂O Poids moléculaire: 198.23 PubChem CID: 91827362

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

5-Methylnaphth[2,1-d]oxazol-2-amine | SKA-121 | 5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine | SKA121 | 5-methyl-naphth[2,1-d]oxazol-2-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Product description：

SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.

Specifications

Synonymes

5-Methylnaphth[2,1-d]oxazol-2-amine | SKA-121 | 5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine | SKA121 | 5-methyl-naphth[2,1-d]oxazol-2-amine

Spécifications et pureté

Moligand™, ≥98%(HPLC)

Mécanismes biochimiques et physiologiques

Positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50= 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KVand NaVchannels. Potentiates bradykinin-induce

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ACTIVATOR

Mécanisme d'action

Activator of K Ca3.1

Pureté

≥98%(HPLC)

Noms et identifiants

• Sourires canoniques: CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N
• IUPAC Name: 5-methylbenzo[g][1,3]benzoxazol-2-amine
• InChIKey: JEGUERWMMMQFJV-UHFFFAOYSA-N
• INCHI: 1S/C12H10N2O/c1-7-6-10-11(15-12(13)14-10)9-5-3-2-4-8(7)9/h2-6H,1H3,(H2,13,14)
• Isomères SMILES: CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N
• PubChem CID: 91827362
• Termes d'entrée MeSH: 5-methylnaphtho(2,1-d)oxazol-2-amine;SKA-121
• Poids moléculaire: 198.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Naphthalenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Naphthalenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenes
• Alternative Parents: Benzoxazoles Oxazoles Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Primary amines Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Naphthalene - Benzoxazole - Azole - Oxazole - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Oxacycle - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 19.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.91, Max Conc. mM: 50
• Poids moléculaire: 198.220 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 198.079 Da
• Monoisotopic Mass: 198.079 Da
• Topological Polar Surface Area: 52.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1