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SLIGRL-NH₂, Agonist of PAR2, CAS No.rp174989, Agonist of PAR2

CAS: rp174989 Cat. No.: rp174989
COA
SLIGRL-NH₂, Agonist of PAR2, CAS No.rp174989, Agonist of PAR2
DISPONIBLE À COMMANDE
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
★
Size
Allemagne (EU)
USA*
Price
Qty
500μg
rp174989-500μg
Sur commande · 8–12 semaines
2 082,49€
1mg
rp174989-1mg
Sur commande · 8–12 semaines
3 470,87€
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Specifications Stockage et expédition Documentation Advanced Data Cibles associées (humaines) Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Informations génétiques Calculateurs de solution Avis Foire aux questions Application Protocols Biological Roles Buffer Applications Green Alternatives Pharmaceutical Uses Physical Properties Quality and Grades Reaction and Applications Reaction Conditions Safety and Handling Solvent Selection Storage and Reconstitution Structure and Identity Synthetic Utility Target Specificity
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Why this grade

Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Product Name
SLIGRL-NH₂, Agonist of PAR2, CAS No.rp174989
Grade
Moligand™
Spécifications et pureté
Moligand™
Type d'action
AGONIST
Mécanisme d'action
Agonist of PAR2
CAS
rp174989
Type de molécule
Peptide
Product Line
Produits biologiques
Stockage et expédition
Conditions de stockage de stockage
Room temperature

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Cibles associées (humaines)
F2RL1 Tchem Proteinase-activated receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Informations génétiques
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
Calculateurs de solution
Avis

Avis des clients

Application Protocols

No manufacturer-tested protocols are provided in the Product Data for this item.

  • General literature-style guidance for use in cell-based assays:
    • Reconstitution: dissolve in sterile water or minimal DMSO, then dilute into pre-warmed assay buffer.
    • Concentration–response: prepare serial dilutions (e.g., 1:3 or 1:10) to cover sub- to supra-maximal ranges; measure EC50/efficacy as appropriate for your readout.
    • Assay readouts: Ca2+ mobilization (dye-based or genetically encoded indicators), ERK phosphorylation (Western blot/ELISA), or reporter assays; select per your pathway of interest.
    • Controls: include vehicle, unrelated peptide control, and pathway inhibitors as needed.

These are general suggestions based on literature practice for this peptide class and are not validated protocols for this specific item. Consult primary literature and adapt to your instrumentation and cell model.

Biological Roles

  • Item-specific biological annotations: Not provided in Product Data.

  • Literature context for the peptide SLIGRL-NH2:

    • Functional role: commonly used as an agonist peptide for Protease-Activated Receptor-2 (PAR2), a GPCR activated by proteolytic unmasking of a tethered ligand sequence. SLIGRL-NH2 mimics the tethered ligand to activate the receptor in a controllable, protease-independent manner.
    • Pathways studied: GPCR signaling cascades including Gq/11-mediated Ca2+ mobilization, PKC activation, MAPK/ERK pathways, and related transcriptional responses in relevant cell models.
    • Experimental utility: enables probing receptor pharmacology, desensitization/re-sensitization, receptor trafficking, and biased signaling profiles across cell types.
    • Selectivity considerations: activity profile depends on species isoforms and receptor expression levels; off-target effects can occur at higher concentrations, so appropriate controls are recommended.

These points summarize common literature usage of the SLIGRL-NH2 sequence as a research ligand. They do not imply any clinical or therapeutic role. For this specific catalog item, consult experimental data and CoA for any validated activities if provided.

Buffer Applications

This product is a functional peptide ligand and is not typically used as a buffering agent.

  • Practical lab relevance (literature/typical practice):
    • Reconstitution and working solutions are often prepared in biological buffers (e.g., PBS, HEPES, or assay-specific media) at pH 6–7.4 to maintain peptide stability and biological activity.
    • For initial dissolution, a small amount of DMSO or dilute acid (e.g., 0.1% acetic acid) can be used before buffer dilution if needed for challenging sequences.
    • Filter sterilization (0.22 µm) of aqueous solutions may be used for cell-based assays; confirm peptide recovery to avoid losses to filters.

If buffering capacity or pH control is required, select an appropriate independent buffer system for your assay. No dedicated buffer formulation is specified for this item in the Product Data.

Green Alternatives

This product is a peptide ligand rather than a solvent or bulk reagent; “greener” considerations focus on solvent and workflow choices during use.

  • Preferred media (greener practice; literature):

    • Use aqueous buffers (PBS, HEPES, Tris) as the primary vehicle for assays whenever possible.
    • Minimize DMSO content by preparing the highest practical aqueous stock or by co-solubilizing with minimal DMSO before buffer dilution.

  • Alternatives and trade-offs:

    • Water/buffer vs DMSO: water is the greenest and safest vehicle; DMSO offers higher solubility but introduces toxicity/biological effects at elevated percentages.
    • Ethanol as a co-solvent is generally less effective for peptides and can impact biological systems; avoid unless validated.

  • Process tips:

    • Prepare small, single-use aliquots to reduce waste from expired solutions.
    • Use reusable glass vials where appropriate and rinse with water/ethanol instead of halogenated solvents.
    • Plan experiments to minimize discarded, partially used peptide stocks.

Because the item is not a volatile organic solvent, substitution with “green” solvents does not apply directly; instead, optimize dissolution and dilution into aqueous systems to reduce organic solvent use and waste.

Pharmaceutical Uses

No pharmaceutical or clinical use is claimed or provided for this item. It is designated For research use only in the Product Data.

  • Literature/industry context (general, non-clinical):
    • Short peptides like SLIGRL-NH2 are often employed as reference ligands or positive controls in discovery biology, high-content screening, and mechanistic studies of receptor signaling.
    • As an unlabeled research peptide, it is not an excipient and has no pharmacopeial status implied.
    • Any formulation discussions for parenteral or clinical use are out of scope; researchers should limit use to in vitro or exploratory preclinical experiments consistent with institutional policies.

For manufacturing, regulatory, or GMP-related applications, this catalog listing provides no such qualification. Verify all quality attributes on the CoA if adapting to regulated research contexts (e.g., GLP assays), but note that no regulatory suitability is stated.

Physical Properties

  • Item-specific values from Product Data:

    • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
    • Appearance: Not specified for this item; refer to CoA/Spec Sheet.

  • Literature/typical properties for SLIGRL-NH2 (peptide):

    • Physical state: typically an off-white to white solid lyophilizate (literature).
    • Solubility: readily soluble in water, aqueous buffers (pH ~4–8), and polar aprotic solvents (DMSO, DMF) at assay concentrations; limited solubility in alcohols; insoluble in nonpolar solvents (literature).
    • pI/charge (predicted): net positive at neutral pH due to the Arg guanidinium and free N-terminus; C-terminal amidation removes one acidic group (literature).
    • LogP: expected very low/negative (highly polar peptide; literature expectation rather than a specification).
    • Melting behavior: peptides typically do not show a sharp melting point and may decompose on heating >200 °C (literature).
    • Hygroscopicity: many small peptides can be hygroscopic; handle quickly in ambient air to minimize moisture uptake (literature).

All numerical specifications for this specific lot/item should be confirmed on the CoA/Spec Sheet. Values above are general literature behavior for this sequence and are not item specifications.

Quality and Grades

  • Item-specific grade from Product Data:

    • Grade: Moligand™

  • Interpretation and implications:

    • Moligand™ (general description): positioning suggests a library/ligand screening grade intended for discovery workflows (e.g., target engagement assays, receptor activation screens, binding profiling). This typically emphasizes identity and usability in biological assays over chromatographic solvent characteristics. Exact grade criteria for this item are not specified; consult the CoA for identity, purity, counter-ion, and residual solvent information.
    • Peptide-specific considerations: for biological assays, peptide identity is commonly verified by LC–MS and purity by analytical HPLC. Common counter-ions include acetate, trifluoroacetate (TFA), or chloride; counter-ion identity can influence solubility and assay background and should be checked on the CoA.
    • UV/Fluorescence: unlabeled peptide; no spectroscopic grade is implied.
    • Stabilizers/additives: Not specified for this item; refer to CoA/Spec Sheet.

  • What to verify on receipt:

    • Certificate of Analysis: sequence confirmation, purity (%), counter-ion/salt form, water content, residual solvents, and recommended dissolution conditions.
    • Lot-to-lot consistency: confirm assay response in your system, especially for functional ligands.

Note: No specific purity percentage or stabilizer is provided in the Product Data for this item.

Reaction and Applications

  • Item-specific manufacturer applications: Not specified in Product Data beyond category placement in a small-molecule/compound library.

  • Literature/typical research applications for SLIGRL-NH2:

    • Widely used as a functional agonist peptide in receptor pharmacology, especially for Protease-Activated Receptor-2 (PAR2) assay systems, to probe downstream signaling (Ca2+ mobilization, ERK phosphorylation) in cells expressing PAR2.
    • Benchmark ligand in GPCR screening cascades to validate pathway integrity, define EC50 windows, and standardize assay conditions across plates.
    • Tool compound for studying desensitization, internalization, biased signaling, and cross-talk with other receptors in cellular models.

  • Practical considerations:

    • Prepare concentrated stocks (e.g., 1–10 mM) in water or DMSO, then dilute into assay buffer; avoid repeated freeze–thaw by aliquoting.
    • Verify receptor expression and responsiveness in your system; include vehicle controls. Titrate concentration to establish full concentration–response curves.
    • For plate-based Ca2+ assays, ensure consistent loading times and temperature control; for kinase readouts, synchronize treatment times.

Note: The above are literature/common uses for this peptide sequence and are not item-specific validated applications. No medical or clinical uses are implied.

Reaction Conditions

Classical organic reaction conditions are not generally applicable to a finished peptide ligand. Instead, users typically require biological assay conditions.

  • Literature/typical assay conditions for SLIGRL-NH2:
    • Stock solutions: prepare at 1–10 mM in water or DMSO; store aliquots to avoid freeze–thaw.
    • Working concentrations: commonly in the 0.1–100 µM range depending on cell type, receptor expression, and assay modality (e.g., Ca2+ flux vs ERK phosphorylation). Optimize via concentration–response curves.
    • Vehicles: aim for ≤0.5–1% DMSO final in cell-based assays; use buffered saline (e.g., HBSS, PBS) with appropriate supplements for live-cell measurements.
    • Temperature and timing: room temperature to 37 °C depending on assay; acute stimulations often 1–30 minutes for signaling readouts; longer exposures may induce desensitization—design protocols accordingly.
    • Controls: include vehicle controls, non-responsive cell lines, or receptor antagonists/siRNA where applicable to confirm pathway specificity.

All values above are general literature guidance, not specifications for this item. Users should validate conditions in their own systems and consult primary literature relevant to their model.

Safety and Handling

  • Item-specific hazard details from Product Data:

    • GHS Classification: Not specified for this item; refer to SDS.
    • Signal Word: Not specified for this item; refer to SDS.
    • H-Statements: Not specified for this item; refer to SDS.
    • Pictograms: Not specified for this item; refer to SDS.

  • General safety guidance for research peptides (literature/good practice):

    • Expected hazards: low volatility; dust may cause mechanical irritation to eyes/respiratory tract. Avoid inhalation of powders and contact with eyes/skin.
    • PPE: lab coat, safety glasses, and suitable gloves (e.g., nitrile). Use a dust mask or work in a fume hood/biological safety cabinet when weighing powders to minimize aerosol exposure.
    • Handling: minimize repeated freeze–thaw of solutions; prepare single-use aliquots. Use clean, low-protein-binding plasticware to reduce adsorption losses.
    • Incompatibilities: avoid strong oxidizers and strong acids/bases that may hydrolyze peptide bonds; avoid prolonged exposure to elevated temperatures.
    • First aid (overview; defer to SDS): rinse eyes/skin with water upon contact; move to fresh air if dust is inhaled; seek medical attention if symptoms persist.

Always consult the product-specific SDS for authoritative hazard classification, response measures, and local regulatory guidance. For research use only (per Product Data).

Solvent Selection

As a short, polar peptide, SLIGRL-NH2 dissolves best in aqueous or highly polar organic media.

  • Item-specific solvent data: Not specified for this item; refer to CoA/Spec Sheet.

  • Literature/typical guidance for small peptides:

    • Primary choices: water, PBS, or physiological buffers (pH 6–7.4). If initial dissolution is difficult, pre-wet with a small volume of DMSO (or 10–20% acetic acid for very basic peptides), then dilute with buffer.
    • Polar aprotic solvents: DMSO or DMF can dissolve higher concentrations; subsequently dilute into assay buffer while avoiding precipitation. Keep final DMSO ≤0.5–1% v/v for cell-based assays to minimize solvent effects.
    • Avoid: nonpolar solvents (hexanes, ethers) and high percentages of alcohols that can precipitate peptides.

  • Practical tips:

    • Sequence contains Arg (basic) and amidated C-terminus, providing positive charge; dissolution is usually straightforward in water. Gentle sonication can help.
    • Filter sterilization (0.22 µm) is acceptable for aqueous solutions if required by your workflow; check for adsorption losses.

  • Brief comparison (literature):

    • Water/buffer: best for biological assays; minimal vehicle effects.
    • DMSO: maximal solubility for stock; may affect cells/proteins at higher %.
    • DMF: strong solvent for peptides; less common in bioassays; harder to remove.
Storage and Reconstitution

  • Item-specific storage/shipping from Product Data:

    • Storage Conditions: Room temperature
    • Shipped In: Not specified for this item; refer to CoA/Spec Sheet.

  • General guidance (literature/best practice for peptides):

    • Solid form: store desiccated, protected from light, tightly capped. Although room temperature is indicated, many users prefer 2–8 °C for extended storage; follow the CoA and internal SOPs.
    • Reconstitution: dissolve in sterile water or a minimal amount of DMSO, then dilute with buffer to desired concentration. For difficult dissolution, brief sonication may help. Avoid strong acids/bases.
    • Aliquoting: prepare single-use aliquots; store frozen (−20 to −80 °C) to avoid repeated freeze–thaw of solutions. Thaw on ice and mix gently before use.
    • Stability: aqueous solutions are typically most stable at neutral to slightly acidic pH and when kept cold. Discard if turbidity or precipitation occurs upon dilution.

All storage and reconstitution specifics for this item (including counter-ion, recommended solvent, and solution stability) should be confirmed on the product’s CoA/SDS. For research use only.

Structure and Identity

Short description: SLIGRL-NH2 is a hexapeptide amide with the sequence Ser–Leu–Ile–Gly–Arg–Leu–CONH2, commonly used as a research ligand.

  • Item-specific identifiers from Product Data:

    • SKU: rp174989
    • Product Name: SLIGRL-NH₂
    • CAS: rp174989 (catalog placeholder)
    • Grade: Moligand™
    • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
    • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

  • Literature/typical structural information (for the peptide SLIGRL-NH2):

    • Sequence: H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (N-terminus free amine; C-terminus amidated)
    • Functional groups: primary amines (N-terminus, Arg side chain), hydroxyl (Ser), aliphatic side chains (Leu, Ile), guanidinium (Arg), peptide amide backbone, C-terminal amide.
    • Stereochemistry: typically L-configuration at all residues (literature for standard synthetic peptides).
    • 2D structural features (description): a linear peptide of six alpha-amino acid residues with five peptide bonds; the C-terminus is converted from –COOH to –CONH2.
    • Molecular formula (literature for SLIGRL-NH2): C29H56N10O7
    • Average molecular weight (literature): ~656.83 g/mol; monoisotopic mass ~656.43 Da.

Note: Exact structural identifiers (SMILES, InChI) and confirmations specific to this catalog item are not provided in the Product Data and should be verified on the CoA/Spec Sheet.

Synthetic Utility

This compound is a bioactive peptide ligand rather than a general organic reagent; it is not typically used as a building block in synthetic organic chemistry.

  • Research utility (literature/common practice):

    • As a defined ligand, SLIGRL-NH2 serves as a probe to validate signaling cascades and to benchmark assay windows. It is valuable in SAR studies comparing sequence variants or modifications (e.g., D-residues, N-terminal acetylation, or side-chain substitutions) to map receptor interactions.
    • Can be incorporated into conjugates (e.g., fluorescent labels, biotin) for binding/trafficking studies; such derivatizations are typically performed on protected precursors during solid-phase peptide synthesis (SPPS).

  • Peptide chemistry note:

    • If users plan analog synthesis, the parent sequence provides a template for Ala-scan or residue swaps to explore potency, efficacy, and bias. C-terminal amidation is an important feature affecting charge and receptor activation; maintain or intentionally vary it when designing analogs.

No specific synthetic transformations are recommended for this finished peptide material beyond standard conjugation/derivatization workflows, which require appropriate activated labels and coupling strategies.

Target Specificity

Item-specific target/antigen details are not provided in the Product Data for this catalog entry.

  • No clone, isotype, or species reactivity is applicable (this is a peptide, not an antibody).
  • Any receptor activity or selectivity discussed elsewhere is presented as literature context for the SLIGRL-NH2 sequence and is not a validated specification for this particular item.

For target-related performance data, refer to the CoA or in-house validation results if available.

Foire aux questions

What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is rp174989.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Moligand™ grade guide →
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