SNX7886 - ≥99% , CAS No.2924557-42-4

CAS: 2924557-42-4 Cat. No.: S1449816 Formule: C₅₂H₅₉N₉O₇ Poids moléculaire: 922.08

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

SNX7886 is a potent protac degrader of CDK8/19. SNX7886 degrades CDK 8 and CDK 19 with 90% and 80% degradation in 293 cells, respectively.

Specifications

Spécifications et pureté

≥99%

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

Poids moléculaire

922.08

Application Protocols

No validated, item-specific biological or analytical protocols are provided for SNX7886. The following general procedures are commonly used for small-molecule screening compounds and should be adapted to your assay.

General DMSO stock preparation:

• Equilibrate vial to room temperature in the dark. Quickly weigh the desired amount. Dissolve to prepare a 10–50 mM stock in anhydrous DMSO. Vortex and, if needed, sonicate briefly. Filter through 0.22 µm PTFE if particulates persist.
• Aliquot into amber, low-bind microtubes. Store at −20°C protected from light. Avoid repeated freeze–thaw; use single-use aliquots when possible.

Assay dilution (example framework):

• Prepare serial dilutions in DMSO (e.g., 3-fold series) and back-dilute into assay buffer to achieve final DMSO ≤0.1–1% v/v. Include vehicle controls at matched DMSO.
• Inspect for precipitation after dilution and post-incubation. Where feasible, quantify compound concentration in wells by LC–MS/MS for exposure confirmation.

Analytical method development:

• Start with reversed-phase LC (C18), water/ACN or water/MeOH with 0.1% FA or appropriate buffer. Monitor at 210–254 nm and MS for identity confirmation. Optimize once the UV/ionization properties are known from the CoA.

Biological Roles

• Target, pathway, and mechanism information for SNX7886 are not provided in this listing. No biological role is assigned.

Appropriate research framing (general guidance):

• Treat SNX7886 as an uncharacterized small molecule for exploratory studies. Any observed phenotypic or biochemical activity should be verified with orthogonal assays, counter-screens for assay interference (e.g., aggregation, redox cycling, fluorescence/quenching), and concentration–response analysis.
• For cell-based experiments, determine cytotoxicity windows (e.g., by viability assays) independent of the primary readout. Control the final DMSO concentration and include vehicle controls.
• For biochemical assays, assess potential nonspecific inhibition (e.g., detergent-sensitive aggregation, promiscuous reactivity with cysteines) using standard artifact triage practices.

Data integrity:

• Record exact lot numbers, solution preparation dates, and storage conditions.
• If a specific biological target is later disclosed or identified, capture the binding/kinetic parameters (Kd, IC50, Ki) and assay conditions in your ELN. None are provided here and must not be inferred.

Buffer Applications

SNX7886 is a small molecule and not a buffering agent; conventional buffer formulations (e.g., phosphate, HEPES, Tris) do not apply directly.

Practical notes for incorporating into buffered systems (general guidance):

• Stock preparation: Dissolve in DMSO (e.g., 10–50 mM). Vortex/sonicate under reduced light. Filter if necessary (0.22 µm PTFE for organic solutions).
• Dilution into buffer: Add stock to the assay buffer with vigorous mixing to a final DMSO of ≤0.1–1% v/v, verifying solubility at working concentration. Common buffers include PBS, HEPES, or Tris at pH suitable for the biological system.
• Precipitation checks: After dilution, visually inspect and, if possible, measure light scattering or absorbance at 620–700 nm to detect turbidity.
• Adsorption minimization: Use low-bind plastics or silanized glass for low-nM work to reduce compound loss to surfaces.

If pH-dependent solubility is suspected (based on future structural data), adjust buffer pH near predicted ionization to improve apparent solubility, ensuring compatibility with the assay and target biology.

Green Alternatives

Without structure-specific hazards or solvent needs, green choices focus on dissolution and assay vehicle selection.

Guidance (general, not item-specific):

• Prefer lower-toxicity, biodegradable, and lower VOC solvents when feasible (e.g., ethanol, isopropanol) for preparative steps if they provide sufficient solubility.
• Minimize DMSO concentration in final assays due to environmental and biological compatibility considerations, while recognizing DMSO’s superior solvency.
• Use aqueous buffers at neutral pH when compatible with solubility and stability; consider cyclodextrin inclusion complexes or co-solvent blends to reduce organic solvent content.

Illustrative comparison (general):

• DMSO: Excellent solvency; widely used; moderate environmental impact; typical final assay ≤0.1–1%.
• Ethanol: Greener profile; good solvency for many aromatics and medium-polar compounds; volatility can complicate dosing precision.
• PEG 400/propylene glycol: Useful as co-solvents or vehicles for in vivo method development (research only); higher viscosity; ensure assay compatibility.

Operational practices:

• Right-size aliquots to reduce waste and repeated freeze–thaw.
• Use amber vials and low-light handling to lower degradation and avoid re-preparation cycles.
• Adopt microscale solubility screens to select the least hazardous solvent meeting performance needs.

Pharmaceutical Uses

No pharmacopeial status or excipient/formulation role is provided for SNX7886. The compound is supplied strictly for research use only and is not intended for human or veterinary use.

Research-related formulation context (general, non-clinical):

• May be employed as a research reference material during pre-formulation screening, e.g., assessing solubility, stability, and analytical methods (LC–MS, HPLC-UV) under nonclinical laboratory conditions.
• If used as an internal standard or spike-in control, confirm purity and stability via CoA and in-house verification, and establish solution stability (bench-top, autosampler, freeze–thaw) under your method conditions.
• For any in vitro ADME profiling (e.g., microsomal stability, plasma protein binding), develop compound-specific methods only after obtaining the full structural and analytical data set. None are provided in this listing.

Regulatory note:

• No claims of safety, efficacy, or clinical utility are made or implied. SNX7886 is not approved as a drug substance, excipient, or diagnostic.

Physical Properties

Item-specific physicochemical parameters have not been disclosed for this catalog entry.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point (literature/computed): Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point (literature/computed): Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not specified for this item; refer to CoA/Spec Sheet.
• pKa(s): Not specified for this item; refer to CoA/Spec Sheet.
• logP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• Aqueous solubility: Not specified for this item; refer to CoA/Spec Sheet.
• UV/Vis characteristics: Not specified for this item; refer to CoA/Spec Sheet.

General guidance for small-molecule library members (literature-based, not item-specific):

• Many screening compounds are formulated as solids, with working stocks typically prepared in anhydrous DMSO (e.g., 10–50 mM) followed by dilution into assay buffers (final DMSO often ≤0.1–1% v/v).
• Solubility and stability can vary widely with chemotype (acid/base/neutral, H-bond donors/acceptors, aromaticity). Perform a micro-solubility screen across DMSO, DMF, ethanol, and buffered aqueous systems at assay-relevant pH.
• If the compound is light-sensitive (this item: store protected from light), minimize exposure during weighing, dissolution, and handling.

Quality and Grades

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

Interpretation and expectations:

• Library compounds are typically supplied as solid materials at high chemical purity suitable for discovery workflows (e.g., screening, SAR, reference standards). However, unless the specific purity metric (e.g., HPLC area %, qNMR) is stated on the CoA, users should verify suitability for their application.
• Identity confirmation is generally established by LC–MS and/or NMR. Review the CoA for analytical methods used, acceptance criteria, and lot-specific results.
• If stabilizers, counterions, or specific salt forms are present, they will be disclosed on the CoA. No stabilizer or salt-form information is provided in this entry.
• Chromatographic suitability (e.g., LC–MS compatibility, UV cutoffs) and trace impurity profiles (e.g., residual solvents, inorganic residues) are application- and lot-dependent. When not specified, users should run incoming QC appropriate to their assay (e.g., purity check at method wavelength, orthogonal ID by HRMS).

Recommendations:

• For bioassays, consider re-purifying or micro-filtering DMSO stocks if assay sensitivity to particulates or trace impurities is high.
• For quantitative work (e.g., standard curve generation), verify purity by your in-house method and correct for potency on a mass basis if needed (e.g., accounting for water/solvent of crystallization when disclosed).

Reaction and Applications

This product is positioned as a small-molecule library member for research screening and reference use, not primarily as a synthetic reagent. Typical applications include:

• High-throughput and medium-throughput screening in biochemical or cell-based assays to identify activity profiles and potential targets.
• Tool compound exploration and preliminary structure–activity relationship (SAR) studies once a biological signal is observed.
• Analytical reference standard for method development (e.g., LC–MS retention time locking, recovery assessments) when identity and purity are verified by CoA.

Practical tips for assay deployment:

• Prepare concentrated DMSO stocks (e.g., 10–50 mM) under low light; aliquot to avoid repeated freeze–thaw.
• Validate solubility in relevant assay media at intended top concentration; monitor for precipitation after dilution (0–60 min and after incubation).
• Include vehicle controls (matching DMSO %) and, where applicable, positive/negative control ligands.

Not typically applicable:

• Named synthetic reactions, catalysts, and stoichiometric transformations are generally not relevant unless you repurpose SNX7886 as a substrate or probe in a chemical reaction study. Without structural disclosure, no reaction class can be recommended. If synthetic use is intended, request full structural data and stability profile.

Reaction Conditions

This item is not positioned as a synthetic reagent, and no structure-specific reaction data are provided. Accordingly, standard reaction conditions cannot be defined for SNX7886.

General notes (if using in exploratory chemistry or analytics):

• Solution stability studies: Evaluate in intended solvents (DMSO, MeOH, ACN, buffers) at ambient and 37°C, protected from light, to establish handling windows. Track by LC–MS/UPLC.
• Photostability: Given the storage instruction to protect from light, assess photolability under ambient lab light and UV to inform amberware use and light exposure limits.
• pH stress tests (analytical only): If structural data later indicate ionizable groups or labile linkages, perform acid/base hydrolysis screens (e.g., pH 2, 7.4, 9) to map degradation pathways for method development purposes.

Yield, catalyst, temperature, and time guidelines for named reactions are not applicable without a disclosed chemotype. Consult the CoA/SDS before attempting any chemical transformations.

Safety and Handling

Hazard classification is not specified in this listing. Treat as a laboratory chemical of unknown toxicity and handle under a risk-assessed protocol. Always consult the SDS shipped with your lot for authoritative guidance.

• GHS classification: Not specified for this item; refer to SDS.
• Signal word, hazard statements, pictograms: Not specified for this item; refer to SDS.

Core precautions (good laboratory practice):

• PPE: Use lab coat, safety glasses or face shield, and appropriate chemically resistant gloves (e.g., nitrile). Work in a certified fume hood to avoid inhalation of dusts/aerosols.
• Avoid ingestion, inhalation, skin and eye contact. Do not pipette by mouth. Wash hands thoroughly after handling.
• Incompatibilities: Unknown for this specific item; segregate from oxidizers, strong acids/bases until specific data are confirmed on SDS/CoA.
• Light sensitivity: Store and handle protected from light per item instructions.
• Thermal sensitivity: Store at −20°C. Avoid repeated freeze–thaw of solutions.

First aid (general overview; defer to SDS):

• Inhalation: Move to fresh air; seek medical attention if symptoms occur.
• Skin/eyes: Rinse with water for ≥15 minutes; remove contaminated clothing; seek medical attention if irritation persists.
• Ingestion: Rinse mouth; seek medical attention; do not induce vomiting unless directed by medical personnel.

Waste/disposal: Collect as organic chemical waste; dispose according to institutional, local, and national regulations.

Shipping: Supplied in ice chest with ice pads to preserve stability during transit.

Solvent Selection

Item-specific solubility and polarity parameters are not provided. The following general strategy is recommended for small-molecule library members, especially when light-sensitive and stored at −20°C.

General dissolution hierarchy (practical guidance):

• Primary solvent: Anhydrous DMSO, due to broad solvency and assay compatibility at low final %.
• Secondary solvents (if needed): DMF or NMP (high solvency; verify assay tolerance), ethanol or isopropanol (greener, lower toxicity), acetonitrile or methanol for LC workflows.
• Aqueous systems: If ionizable, dissolve in minimal organic solvent then dilute into buffered aqueous media (typical final DMSO ≤0.1–1% v/v). Adjust pH toward predicted pKa to enhance solubility if compatible with the assay.

Small-scale solubility screen (suggested):

• Prepare 1 mg in 100 µL aliquots; test DMSO, DMF, ethanol, MeOH, ACN at room temperature and 37°C with gentle agitation/sonication. Inspect for clarity and precipitation after 30–60 minutes.

Compatibility notes:

• Avoid prolonged exposure to light during dissolution and handling.
• Filter 0.22 µm if particulate persists and filtration is compatible with your application.
• For LC–MS: Prefer MeOH, ACN, or DMSO; maintain water-miscible co-solvent content to prevent precipitation upon dilution.

Storage and Reconstitution

Storage conditions for this item are explicitly defined; follow strictly to preserve integrity.

• Storage: Store at −20°C, protected from light. Keep container tightly closed. Record the first opening date and maintain a handling log.
• Shipping: Shipped in an ice chest with ice pads to maintain a cold chain during transit.
• Appearance: Not specified for this item; refer to CoA/Spec Sheet.

Reconstitution (general guidance for small molecules):

• Allow vial to equilibrate to room temperature before opening to prevent moisture condensation. Minimize light exposure during handling.
• Prepare concentrated stocks in anhydrous DMSO (e.g., 10–50 mM) unless the CoA indicates preferred solvents. Mix thoroughly; brief sonication may aid dissolution.
• Filter if necessary (0.22 µm PTFE) and dispense into amber, low-bind aliquots sized for single use. Label with concentration, solvent, date, and lot.

Stability recommendations:

• Avoid repeated freeze–thaw; thaw aliquots once and keep on ice and protected from light during use.
• For solution stability, perform short-term studies at bench-top and autosampler conditions relevant to your workflow. Discard solutions showing precipitation, discoloration, or out-of-spec purity.

Any unspecified item-specific parameters (e.g., hydrate/solvate content, exact solubility, degradation kinetics): Not specified for this item; refer to CoA/Spec Sheet.

Structure and Identity

SNX7886 is provided as a research-use small-molecule library member. Item-specific structural identifiers are not disclosed in this listing.

• SKU: S1449816
• Product Name: SNX7886
• CAS: 2924557-42-4
• Category: Small molecules and compound library (research use only)
• Structural identifiers:
  • Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general guidance):

• Functional groups, ring systems, stereochemistry, and ionization state are not provided in the public entry. For any structure-dependent experimental design (e.g., solubility prediction, pKa estimation, or chromatographic method development), please consult the authenticated CoA/Spec Sheet and SDS that ship with the lot.

2D/3D representation:

• Not provided in this entry. If you require cheminformatics-ready files (SDF/MOL/SMI) for screening or computational work, request the latest documentation from Aladdin Scientific customer support with your lot/PO number.

Synthetic Utility

SNX7886 is offered as a screening/compound-library small molecule rather than a synthetic building block. Without structural disclosure, synthetic transformations, protecting group strategies, and functional group interconversions cannot be recommended.

Potential research uses adjacent to synthesis (general):

• Analytical standard for method development in synthesis workflows (e.g., spike recovery during purification validation or stability-indicating HPLC methods).
• Degradation pathway studies (forced degradation under light, heat, oxidative and hydrolytic conditions) to define stability profiles that inform handling during medicinal chemistry campaigns—only after structural information is available.

If you intend to employ SNX7886 in chemical synthesis (e.g., as a substrate or probe):

• Obtain the full structure, salt/counterion information, and stability data from the CoA.
• Verify reactivity hazards (e.g., potential electrophilicity/nucleophilicity, redox behavior) and incompatibilities before scaling.
• Start with micro-scale reactions, monitoring by LC–MS to confirm mass balance and identify byproducts. No reaction conditions can be recommended in the absence of structure-specific data.

Target Specificity

Target/epitope/clone data are not applicable to small molecules and none are provided for this item.

• Target name: Not specified for this item; refer to CoA/Spec Sheet if ever disclosed.
• Mechanism of action: Not specified for this item; refer to CoA/Spec Sheet.
• Species reactivity and isotype: Not applicable.

Usage note:

• If target engagement is discovered during your research, document binding parameters, assay format, counterscreens, and orthogonal confirmation methods in your ELN. No target specificity is implied by this listing.