SP 141 - ≥98%(HPLC) , CAS No.1253491-42-7

CAS: 1253491-42-7 Cat. No.: S288439 Formule: C22H16N2O Poids moléculaire: 324.38 PubChem CID: 59620153
DISPONIBLE À COMMANDE
GRADE & PURITY ≥98%(HPLC)
Synonyms
6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
Allemagne (EU)
USA*
Price
Qty
5mg
S288439-5mg
Sur commande · 8–12 semaines

23,34€

35,49€
Enregistrer 12,15 € (34.23%)
10mg
S288439-10mg
Sur commande · 8–12 semaines

41,56€

62,39€
Enregistrer 20,83 € (33.38%)
25mg
S288439-25mg
Sur commande · 8–12 semaines

89,29€

134,41€
Enregistrer 45,12 € (33.57%)
50mg
S288439-50mg
Sur commande · 8–12 semaines

136,15€

204,70€
Enregistrer 68,55 € (33.49%)
100mg
S288439-100mg
—
1 En stock

216,85€

325,32€
Enregistrer 108,47 € (33.34%)
250mg
S288439-250mg
Sur commande · 8–12 semaines

382,59€

574,36€
Enregistrer 191,77 € (33.39%)
Enter a quantity for the sizes you want to add.
🧪
Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Vue d’ensemble

product description:

P-141 is a specific MDM2 inhibitor. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 in potential for cancer research.

Specifications

Synonymes
6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Spécifications et pureté
≥98%(HPLC)
Mécanismes biochimiques et physiologiques
High affinity MDM2 inhibitor (Ki= 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.
Conditions de stockage de stockage
Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Pureté
≥98%(HPLC)
Noms et identifiants
Pubchem Sid
Sourires canoniques
COC1=CC2=C(C=C1)NC3=C2C=CN=C3C4=CC=CC5=CC=CC=C54
IUPAC Name
6-methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
InChIKey
AABFWJDLCCDJJN-UHFFFAOYSA-N
INCHI
1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
Isomères SMILES
COC1=CC2=C(C=C1)NC3=C2C=CN=C3C4=CC=CC5=CC=CC=C54
PubChem CID
59620153
Poids moléculaire
324.38

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassAlkaloids and derivatives
ClasseHarmala alkaloids
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentHarmala alkaloids
Alternative Parents Beta carbolines  Naphthalenes  Indoles  Anisoles  Alkyl aryl ethers  Pyridines and derivatives  Pyrroles  Heteroaromatic compounds  Azacyclic compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Harman - Beta-carboline - Pyridoindole - Naphthalene - Indole - Indole or derivatives - Anisole - Phenol ether - Alkyl aryl ether - Pyridine - Benzenoid - Heteroaromatic compound - Pyrrole - Organoheterocyclic compound - Azacycle - Ether - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as harmala alkaloids. These are compounds with a structure based on harmaline, harmine, harmalol, harman or a derivative of those parents. These parents are beta-carbolines, consisting of a pyrimidine fused to the pyrrole moiety of an indole to form a pyrido[3,4-b]indole.
External Descriptors Not available
Structure 3D
Modèle de structure chimique interactif





Cibles associées (humaines)
Breast carcinoma cell (217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTNNB1 Tchem Catenin beta-1 (517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cibles associées (non humaines)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mécanismes d'action
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateArticle
K2518146Certificate of AnalysisNov 24, 2025 S288439
J2120019Certificate of AnalysisAug 09, 2024 S288439
J2120020Certificate of AnalysisAug 09, 2024 S288439
J2120021Certificate of AnalysisAug 09, 2024 S288439
J2120022Certificate of AnalysisAug 09, 2024 S288439
J2120023Certificate of AnalysisAug 09, 2024 S288439
J2120024Certificate of AnalysisAug 09, 2024 S288439
Propriétés chimiques et physiques
SolubilitéSolvent:DMSO, Max Conc. mg/mL: 32.44, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 32.44, Max Conc. mM: 100
Poids moléculaire324.400 g/mol
XLogP35.200
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass324.126 Da
Monoisotopic Mass324.126 Da
Topological Polar Surface Area37.900 Ų
Heavy Atom Count25
Formal Charge0
Complexity469.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
Calculateurs de solution
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