Stearda - ≥92% , CAS No.105955-10-0

CAS: 105955-10-0 Cat. No.: S334621 Formule: C₂₆H₄₅NO₃ Poids moléculaire: 419.64 PubChem CID: 10025103

GRADE & PURITY ≥92%

Synonyms

CHEBI:186909 | NCGC00092336-01 | n-stearoyl dopamine | DTXSID50434391 | SCHEMBL883453 | Z221503626 | SKN6T3V4BB | n-stearoyldopamine | n-stearoyl-dopamine | PD070686 | J-001506 | N-(3,4-dihydroxyphenethyl)stearamide | N-(2-(3,4-Dihydroxyphenyl)ethyl)-octa

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

STEARDA inhibits arachidonate 5-LO (5-lipoxygenase) with an IC|50|of 16 nM. Adiditionally, is an ndogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. STEARDA is inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, STEARDA potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also, STEARDA inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).

application：

STEARDA is a novel, endogenous capsaicin-like lipid that produces hyperalgesia.

Specifications

Synonymes

CHEBI:186909 | NCGC00092336-01 | n-stearoyl dopamine | DTXSID50434391 | SCHEMBL883453 | Z221503626 | SKN6T3V4BB | n-stearoyldopamine | n-stearoyl-dopamine | PD070686 | J-001506 | N-(3,4-dihydroxyphenethyl)stearamide | N-(2-(3,4-Dihydroxyphenyl)ethyl)-octa

Spécifications et pureté

≥92%

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥92%

Noms et identifiants

• Pubchem Sid: 504765199
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765199
• Sourires canoniques: CCCCCCCCCCCCCCCCCC(=O)NCCC1=CC(=C(C=C1)O)O
• IUPAC Name: N-[2-(3,4-dihydroxyphenyl)ethyl]octadecanamide
• InChIKey: KOCSVLPLQCBIGW-UHFFFAOYSA-N
• INCHI: 1S/C26H45NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26(30)27-21-20-23-18-19-24(28)25(29)22-23/h18-19,22,28-29H,2-17,20-21H2,1H3,(H,27,30)
• Isomères SMILES: CCCCCCCCCCCCCCCCCC(=O)NCCC1=CC(=C(C=C1)O)O
• PubChem CID: 10025103
• Poids moléculaire: 419.64

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenols
      • Subclass Benzenediols
        • Level5 Catechols
          • Level6 Catecholamines and derivatives
            • Level7 N-acyldopamines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenols
• Subclass: Benzenediols
• Intermediate Tree Nodes: Catechols - Catecholamines and derivatives
• Direct Parent: N-acyldopamines
• Alternative Parents: 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Benzene and substituted derivatives Secondary carboxylic acid amides Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: N-acyldopamine - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Fatty acyl - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as n-acyldopamines. These are aromatic heterocyclic compounds containing a dopamine, in which the amine group is acylated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (non humaines)

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble to 5 mM in Ethanol
• Poids moléculaire: 419.600 g/mol
• XLogP3: 7.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 19
• Exact Mass: 419.34 Da
• Monoisotopic Mass: 419.34 Da
• Topological Polar Surface Area: 69.600 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 402.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥92% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 105955-10-0, the molecular formula is C26H45NO3, and the molecular weight is 419.64 g/mol. InChIKey KOCSVLPLQCBIGW-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.