Succinimidyl valeric acid PEG, mPEG-SVA - MW 30000 Da

Cat. No.: S164337

GRADE & PURITY MW 30000 Da

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol valeric acid (PEG-SVA) is an amino (-NH₂) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl valeric acid PEG (mPEG-SVA) offers superior reactivity yet higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Specifications

Spécifications et pureté

MW 30000 Da

Mécanismes biochimiques et physiologiques

Generally, a 10- to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

• Pegylation buffer: PBS buffer, pH 7.4 or other amine-free buffer at pH 7-8.5

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Propriétés chimiques et physiques

• Solubilité: Off-white/white solid or viscous liquid depends on molecule weight;10 mg/mL, clear in water, DMSO, Chloroform