Succinylsulfathiazole - 10mM in DMSO , CAS No.116-43-8

CAS: 116-43-8 Cat. No.: S420750 Formule: C₁₃H₁₃N₃O₅S₂ Poids moléculaire: 355.38 Beilstein Registry Number: 27(3/4)4637 Numéro CE: 204-141-0 PubChem CID: 5315

GRADE & PURITY 10mM in DMSO

Synonyms

succinylsulfathiazole|116-43-8|Colistatin|Cremosuxidine|Sulfasuxidine|Sulfadigesin|Sulfasuccidine|Sulfasuccithiazole|Succinylsulphathiazole|Sulfasuccinil|Kaoxidin|Kaoxidine|4'-(2-Thiazolylsulfamoyl)succinanilic acid|Sulfasuccidin|Sulfenterone|Thiacyl|Rols

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Succinylsulfathiazole is used to block the synthesis of folic acid. It is used to study folate deficiency. It is used to suppress folate production by bacteria in the intestine.

Specifications

Synonymes

succinylsulfathiazole | 116-43-8 | Colistatin | Cremosuxidine | Sulfasuxidine | Sulfadigesin | Sulfasuccidine | Sulfasuccithiazole | Succinylsulphathiazole | Sulfasuccinil | Kaoxidin | Kaoxidine | 4'-(2-Thiazolylsulfamoyl)succinanilic acid | Sulfasuccidin | Sulfenterone | Thiacyl | Rols

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Succinylsulfathiazole is a competitive inhibitor of dihydropteroate synthetase. It is a dihydrofolate reductase (DHFR) inhibitor.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Pubchem Sid: 528773306
• Sourires canoniques: C1=CC(=CC=C1NC(=O)CCC(=O)O)S(=O)(=O)NC2=NC=CS2
• IUPAC Name: 4-oxo-4-[4-(1,3-thiazol-2-ylsulfamoyl)anilino]butanoic acid
• InChIKey: SKVLYVHULOWXTD-UHFFFAOYSA-N
• INCHI: 1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)
• Isomères SMILES: C1=CC(=CC=C1NC(=O)CCC(=O)O)S(=O)(=O)NC2=NC=CS2
• RTECS: WM4767000
• PubChem CID: 5315
• Poids moléculaire: 355.38
• Beilstein: 27(3/4)4637
• Reaxy-Rn: 349989

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonamides
• Alternative Parents: Anilides Benzenesulfonyl compounds N-arylamides Organosulfonamides Fatty amides Thiazoles Aminosulfonyl compounds Heteroaromatic compounds Secondary carboxylic acid amides Monocarboxylic acids and derivatives Azacyclic compounds Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzenesulfonamide - Anilide - Benzenesulfonyl group - N-arylamide - Fatty amide - Organosulfonic acid amide - Fatty acyl - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Azole - Sulfonyl - Aminosulfonyl compound - Thiazole - Carboxamide group - Secondary carboxylic acid amide - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Carbonyl group - Organic oxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
• External Descriptors: 1,3-thiazole

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Poids moléculaire: 355.400 g/mol
• XLogP3: -0.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 355.03 Da
• Monoisotopic Mass: 355.03 Da
• Topological Polar Surface Area: 162.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 526.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1