TAK-653 - ≥98% , Glutamate receptor ionotropic AMPA positive allosteric modulator, CAS No.1358751-06-0, Glutamate receptor ionotropic AMPA positive allosteric modulator

CAS: 1358751-06-0 Cat. No.: T648005 Formule: C₁₉H₂₃N₃O₃S Poids moléculaire: 373.47 PubChem CID: 56655833

GRADE & PURITY ≥98%

Synonyms

TAK-653 | CHEMBL4594403 | Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide | MS-26031 | 9E3TOE5RIZ | EX-A6607 | SCHEMBL622985 | Osavampator

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models.

Specifications

Synonymes

TAK-653 | CHEMBL4594403 | Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide | MS-26031 | 9E3TOE5RIZ | EX-A6607 | SCHEMBL622985 | Osavampator

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.

Conditions de stockage de stockage

Protected from light,Store at -20°C,Desiccated

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

POSITIVE ALLOSTERIC MODULATOR

Mécanisme d'action

Glutamate receptor ionotropic AMPA positive allosteric modulator

Pureté

≥98%

Propriétés du produit

• ALogP: 2.7

Noms et identifiants

• Pubchem Sid: 528767344
• Sourires canoniques: CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4
• IUPAC Name: 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide
• InChIKey: PXJBHEHFVQVDDS-UHFFFAOYSA-N
• INCHI: 1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
• Isomères SMILES: CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4
• PubChem CID: 56655833
• Poids moléculaire: 373.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenol ethers

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenol ethers
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenol ethers
• Alternative Parents: Phenoxy compounds Alkyl aryl ethers Imidolactams Organosulfonic acids and derivatives Tertiary amines Ketimines Propargyl-type 1,3-dipolar organic compounds Enamines Azacyclic compounds Amidines Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenoxy compound - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Imidolactam - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Ketimine - Tertiary amine - Amidine - Enamine - Ether - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic oxide - Imine - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriétés chimiques et physiques

• Solubilité: DMSO : ≥ 12.5 mg/mL (33.47 mM)
• Sensibilité: light & Moisture sensitive
• Poids moléculaire: 373.500 g/mol
• XLogP3: 2.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 373.146 Da
• Monoisotopic Mass: 373.146 Da
• Topological Polar Surface Area: 79.700 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 722.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1