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| Description | Serine/threonine-protein kinase mTOR |
|---|
Gene and Protein Information
| Gene ID | 2475 |
|---|---|
| Uniprot Accession IDs | P42345 Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3 |
| Ensembl ID | ENSP00000354558 |
| Symbole | FRAP FRAP1 FRAP2 RAFT1 RAPT1 SKS FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
| Family | Belongs to the PI3/PI4-kinase family. |
| Sequence | MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW Afficher plus |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Nom | Numéro d'identification fiscale | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 457945 | MTOR | mechanistic target of rapamycin kinase | 9598 | VGNC:8416 | OMA, EggNOG |
| Macaque | 106992736 | MTOR | mechanistic target of rapamycin kinase | 9544 | OMA, EggNOG | |
| Mouse | 56717 | Mtor | mechanistic target of rapamycin kinase | 10090 | MGI:1928394 | Inparanoid, OMA, EggNOG |
| Rat | 56718 | Mtor | mechanistic target of rapamycin kinase | 10116 | RGD:68371 | Inparanoid, OMA, EggNOG |
| Dog | 478232 | MTOR | mechanistic target of rapamycin kinase | 9615 | VGNC:43490 | Inparanoid, OMA, EggNOG |
| Horse | 100051341 | MTOR | mechanistic target of rapamycin kinase | 9796 | VGNC:20434 | Inparanoid, OMA, EggNOG |
| Cow | 100139219 | MTOR | mechanistic target of rapamycin kinase | 9913 | VGNC:31748 | Inparanoid, OMA, EggNOG |
| Pig | 100127359 | MTOR | mechanistic target of rapamycin kinase | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100619675 | MTOR | mechanistic target of rapamycin kinase | 13616 | Inparanoid, OMA, EggNOG | |
| Chicken | 419455 | MTOR | mechanistic target of rapamycin | 9031 | CGNC:2430 | Inparanoid, OMA, EggNOG |
| Anole lizard | 100565267 | mtor | mechanistic target of rapamycin kinase | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | XB-GENE-994583 | Putative ortholog of fKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (MTOR), 1 of 2 [Source:Xenbase;Acc:XB-GENE-994583] | 8364 | OMA, EggNOG | ||
| Zebrafish | 324254 | mtor | mechanistic target of rapamycin kinase | 7955 | ZDB-GENE-030131-2974 | Inparanoid, OMA, EggNOG |
| C. elegans | 172167 | let-363 | Target of rapamycin homolog | 6239 | Inparanoid, OMA | |
| Fruitfly | 47396 | Tor | Target of rapamycin | 7227 | FBgn0021796 | Inparanoid, EggNOG |
| S.cerevisiae | 853632 | TOR2 | phosphatidylinositol kinase-related protein kinase TOR2 | 4932 | S000001686 | Inparanoid, OMA |
| S.cerevisiae | 853529 | TOR1 | phosphatidylinositol kinase-related protein kinase TOR1 | 4932 | S000003827 | OMA, EggNOG |
Associated Recombinant Proteins
| Nom | Specification and purity | Expression system | Protein label | Disponibilité | Voir les détails |
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Associated Antibodies
| Nom | Spécifications | Species reactivity | Application | Disponibilité | Voir les détails |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Nom | Direct Associated Targets | Disease Type | Mondoid |
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Bibliography
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