tBID - Moligand™,10mM in DMSO , CAS No.1639895-85-4

CAS: 1639895-85-4 Cat. No.: T656448 Formule: C₁₁H₃Br₄N₃O₂ Poids moléculaire: 528.78

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 ( HIPK2 ) with an IC 50 of  0.33 µM.

In Vitro

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC 50 =0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 0.33 µM (HIPK2)

Specifications

Spécifications et pureté

Moligand™,10mM in DMSO

Mécanismes biochimiques et physiologiques

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 ( HIPK2 ) with an IC 50 of u200a0.33 µM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Noms et identifiants

• Poids moléculaire: 528.78

Foire aux questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1639895-85-4, the molecular formula is C11H3Br4N3O2, and the molecular weight is 528.78 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.